2024
Biomarkers and molecular endotypes of sarcoidosis: lessons from omics and non-omics studies
Ji H, Xi N, Mohan C, Yan X, Jain K, Zang Q, Gahtan V, Zhao R. Biomarkers and molecular endotypes of sarcoidosis: lessons from omics and non-omics studies. Frontiers In Immunology 2024, 14: 1342429. PMID: 38250062, PMCID: PMC10797773, DOI: 10.3389/fimmu.2023.1342429.Peer-Reviewed Original ResearchConceptsMolecular endotypesChronic granulomatous disorderSarcoidosis biomarkersTNF blockadeDifferentiate sarcoidosisGranulomatous disorderSarcoidosisAdvanced omics approachesHealthy controlsDisease heterogeneityEndotypesDocumented biomarkerBiomarker profilesPersonalized medicineBiomarkersOmics approachesOmics studiesDiseaseDiagnosisTargeted studiesOmicsBlockadePrognosisTherapyEtiology
2023
Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis?
Yan X, Kaminski N. Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis? American Journal Of Respiratory And Critical Care Medicine 2023, 208: 1150-1151. PMID: 37856835, PMCID: PMC10868359, DOI: 10.1164/rccm.202310-1774ed.Peer-Reviewed Original Research
2022
Emerging insights in sarcoidosis: moving forward through reverse translational research
Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Emerging insights in sarcoidosis: moving forward through reverse translational research. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l518-l525. PMID: 35196896, PMCID: PMC8957321, DOI: 10.1152/ajplung.00266.2021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTranslational researchFibrotic lung diseasePulmonary granuloma formationReverse translational researchChronic granulomatous diseaseImmunopathogenic mechanismsLung diseaseUnknown etiologyGranulomatous diseaseGranuloma formationSarcoidosis researchStage IVDisease pathogenesisClinical phenotypeSarcoidosisClinical interventionsDisease model developmentFibrogenesisSignificant proportionFundamental mediatorDiseaseFurther investigationInvestigative effortsHypothesis-driven researchMorbidity
2016
Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma
Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Annals Of The American Thoracic Society 2016, 13 Suppl 1: s104-5. PMID: 27027945, PMCID: PMC5015745, DOI: 10.1513/annalsats.201510-681mg.Peer-Reviewed Original ResearchNitric oxide levelsOxide levelsHigher bronchodilator responseHistory of intubationNormal lung functionClusters of patientsCommon transcriptomic signaturesHigh ratePrebronchodilator FEV1Severe asthmaSteroid requirementsInflammatory characteristicsLung functionBronchodilator responseControl subjectsAsthmaHeterogeneous diseaseClinical phenotypeGene signaturePhysiologic characteristicsWhole bloodTranscriptomic signaturesCluster 1DiseaseHospitalization