2024
Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor type
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individuals
2013
Association of the dopamine β‐hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia
Zhou N, Yu Q, Li X, Yu Y, Kou C, Li W, Xu H, Luo X, Zuo L, Kosten TR, Zhang XY. Association of the dopamine β‐hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia. Human Psychopharmacology Clinical And Experimental 2013, 28: 230-237. PMID: 23559427, DOI: 10.1002/hup.2311.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaPositive symptomsDel polymorphismSeverity of TDAIMS total scoreDel/del genotypeBp insertion/deletion polymorphismIns/ins genotypeNegative Syndrome ScaleSignificant differencesInsertion/deletion polymorphismConversion of dopamineIns/delSymptom subscoresChinese patientsTD patientsDopaminergic neurotransmissionHealthy controlsMovement ScaleDBH activityPatientsSyndrome ScaleDel genotypeTD severity