2024
Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathwayCorrelation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor type
2021
Psychological responses among nurses caring for patients with COVID-19: a comparative study in China
Ren H, Luo X, Wang Y, Guo X, Hou H, Zhang Y, Yang P, Zhu F, Hu C, Wang R, Sun Y, Du Y, Yin Q, Xu G, Zuo H, Hu Q, Wang Y. Psychological responses among nurses caring for patients with COVID-19: a comparative study in China. Translational Psychiatry 2021, 11: 273. PMID: 33958579, PMCID: PMC8101604, DOI: 10.1038/s41398-020-00993-1.Peer-Reviewed Original ResearchConceptsFrontline nursesShort-term psychological impactMental health careCOVID-19Self-administered questionnaireNon-Hubei provincesProbable depressionHealthcare nursesLess social supportDepressive symptomsPsychological responsesNursesMedical staffHigher depressionHubei ProvinceHealth careCOVID-19 outbreakSurvey-based studyPsychological impactConsiderable riskSocial supportWuhanDepressionOutbreakOutbreak of epidemics
2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expressionAmplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI
Mu Y, Li Y, Zhang Q, Ding Z, Wang M, Luo X, Guo X, Xu M. Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI. General Psychiatry 2020, 33: e100147. PMID: 32695958, PMCID: PMC7351268, DOI: 10.1136/gpsych-2019-100147.Peer-Reviewed Original ResearchBilateral superior frontal gyrusAlzheimer's diseaseSuperior frontal gyrusMiddle frontal gyrusFrontal gyrusInferior frontal gyrusResting-state functional magnetic resonance imagingZhejiang Provincial People's HospitalBrain functional alterationsMechanisms of ADLow-frequency fluctuationsBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingResting-state fMRIALFF valuesPathophysiologic featuresPeople's HospitalInclusion criteriaDepressive symptomsFunctional alterationsPatientsResonance imagingLeft inferior frontal gyrusCore symptomsPsychometric properties of the MATRICS Consensus Cognitive Battery (MCCB) in Chinese patients with major depressive disorder
Liang S, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Zhang Y. Psychometric properties of the MATRICS Consensus Cognitive Battery (MCCB) in Chinese patients with major depressive disorder. Journal Of Affective Disorders 2020, 265: 132-138. PMID: 32090734, DOI: 10.1016/j.jad.2020.01.052.Peer-Reviewed Original ResearchConceptsMajor depression disorderMATRICS Consensus Cognitive BatteryMDD patientsCognitive impairmentChinese patientsConsensus Cognitive BatteryBipolar disorderHamilton Depression Rating Scale-17Cognitive AssessmentChinese MDD patientsMajor depressive disorderSeverity of symptomsMontreal Cognitive AssessmentConcurrent validityMild cognitive impairmentCognitive batteryPsychometric propertiesGood concurrent validityMedication treatmentDepressive disorderHealthy controlsGood internal consistencyDepressive symptomsDepression disorderPatients