Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1
Wu B, Geng S, Bi Y, Liu H, Hu Y, Li X, Zhang Y, Zhou X, Zheng G, He B, Wang B. Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1. MSphere 2015, 22: 883-895. PMID: 26018534, PMCID: PMC4519715, DOI: 10.1128/cvi.00170-15.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaveolin 1Dendritic CellsFemaleHerpesvirus 1, HumanHost-Pathogen InteractionsImmune ToleranceLungMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IISurvival AnalysisConceptsInducible nitric oxide synthaseDendritic cellsHSV-1 infectionCav-1HSV-1Nitric oxideHerpes simplex virus 1 (HSV-1) infectionLung dendritic cellsSimplex virus 1 infectionLung pathological changesCav-1 knockout miceNitric oxide synthaseVirus-1 infectionWild-type miceHost antiviral responseHerpes simplex virus 1Cav-1 deficiencySimplex virus 1Adoptive transferCaveolin-1Cav-1 knockdownINOS inhibitorOxide synthasePathological changesTherapeutic approaches