2000
GABA release from mouse axonal growth cones
Gao X, van den Pol A. GABA release from mouse axonal growth cones. The Journal Of Physiology 2000, 523: 629-637. PMID: 10718743, PMCID: PMC2269824, DOI: 10.1111/j.1469-7793.2000.t01-1-00629.x.Peer-Reviewed Original ResearchConceptsGABA releaseSynapse formationGrowth conesSpontaneous GABA releaseAxonal growth conesHypothalamic neuronsTransmitter phenotypeAxon terminalsNeurotransmitter receptorsTransgenic miceAction potentialsGABAProtein kinase C activityNeuronal membranesAxonsNeuronal developmentGreen fluorescent proteinKinase C activityNeuronsVesicular mechanismPKC activationFluorescent proteinC activityLow levelsRelease
1999
Neurotrophin‐3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat
Gao X, van den Pol A. Neurotrophin‐3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat. The Journal Of Physiology 1999, 518: 81-95. PMID: 10373691, PMCID: PMC2269394, DOI: 10.1111/j.1469-7793.1999.0081r.x.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCalciumCarbazolesCells, CulturedElectric StimulationEnzyme InhibitorsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGamma-Aminobutyric AcidHypothalamusIndole AlkaloidsMembrane PotentialsNeuronsNeurotrophin 3Patch-Clamp TechniquesProtein-Tyrosine KinasesRatsSynapsesSynaptic TransmissionTetrodotoxinConceptsSpontaneous postsynaptic currentsFrequency of GABANT-3 effectsNeurotrophin-3Postsynaptic currentsHypothalamic neuronesMature neuronesWhole-cell patch-clamp recordingsMiniature post-synaptic currentsGABAergic synaptic transmissionMiniature postsynaptic currentsDose-dependent potentiationPresence of tetrodotoxinAction potential frequencyPeripheral nervous systemPatch-clamp recordingsTyrosine kinase inhibitorsMean amplitudePost-synaptic currentsNon-selective tyrosine kinase inhibitorRat hypothalamic neuronesGABA excitationGABA releaseGABAergic synapsesPresynaptic locus
1998
Glutamate Inhibits GABA Excitatory Activity in Developing Neurons
van den Pol A, Gao X, Patrylo P, Ghosh P, Obrietan K. Glutamate Inhibits GABA Excitatory Activity in Developing Neurons. Journal Of Neuroscience 1998, 18: 10749-10761. PMID: 9852609, PMCID: PMC6793361, DOI: 10.1523/jneurosci.18-24-10749.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalciumCells, CulturedCerebral CortexEmbryo, MammalianExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidGene ExpressionGlutamic AcidGramicidinHypothalamusIn Vitro TechniquesNeuronsPatch-Clamp TechniquesPresynaptic TerminalsPropionatesRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateSpinal CordConceptsGroup III mGluRsExcitatory actionGABA activityGroup II metabotropic glutamate receptorsFura-2 digital imagingSynapse formationBrain developmentInhibitory roleAgonist L-AP4Excitatory GABA actionsGlutamate-mediated inhibitionMetabotropic glutamate receptorsSpinal cord neuronsMajor inhibitory neurotransmitterWhole-cell recordingsSimilar inhibitory actionBrain GABAEarly brain developmentExcitatory roleGABA releaseL-AP4Excitatory transmitterGABA actionHypothalamic neuronsCord neurons