2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activation
2021
Antigen-Presenting Cells in Food Tolerance and Allergy
Liu EG, Yin X, Swaminathan A, Eisenbarth SC. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers In Immunology 2021, 11: 616020. PMID: 33488627, PMCID: PMC7821622, DOI: 10.3389/fimmu.2020.616020.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsDendritic cellsOral toleranceFood allergyT cellsDifferent antigen-presenting cellsB cell antibody responseLife-threatening anaphylaxisT cell responsesImmunoglobulin E antibodiesVariety of symptomsAPC subsetsFood antigensFood toleranceAntibody responseE antibodiesAntigen presentationImmune responseMouse modelFood allergensAllergyInitial primingCell responsesPatient samplesAntigen