Competition and synergy of Arp2/3 and formins in nucleating actin waves
Le Chua X, San Tong C, Su M, Xǔ X, Xiao S, Wu X, Wu M. Competition and synergy of Arp2/3 and formins in nucleating actin waves. Cell Reports 2024, 43: 114423. PMID: 38968072, PMCID: PMC11378572, DOI: 10.1016/j.celrep.2024.114423.Peer-Reviewed Original ResearchActin wavesActin regulatory proteinsActin cytoskeletal networkConstitutively active mutantArp2/3 complexActin assemblyMonomeric actinActive Cdc42Cdc42-interactingCytoskeletal networkArp2/3Active mutantCellular processesRegulatory proteinsUpstream regulatorCdc42ActinPlasma membraneFMNL1Complex feedback loopsForminPhysiological stateDelayed recruitmentFeedback loopGTPaseNonlinear dynamics in phosphoinositide metabolism
Fung S, Xǔ X, Wu M. Nonlinear dynamics in phosphoinositide metabolism. Current Opinion In Cell Biology 2024, 88: 102373. PMID: 38797149, PMCID: PMC11186694, DOI: 10.1016/j.ceb.2024.102373.Peer-Reviewed Original ResearchMetabolic networksPhosphoinositide metabolismNegative feedback loopCellular physiologyEnzymatic functionSignaling complexSignal transductionMembrane dynamicsNetwork motifsMetabolic pathwaysLipid fluxCellular behaviorMolecular circuitsPhosphoinositideFeedforward loopProducts of metabolismMetabolismFeedback loopExperimental challengeNonlinear dynamicsMotifFramework of nonlinear dynamicsTransductionExcited statesComprehensive understanding