Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 1999, 48: 584-587. PMID: 10078560, DOI: 10.2337/diabetes.48.3.584.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusSystemic hypoglycemiaChronic hypoglycemiaCellular glucopeniaDefective counterregulationDiabetic BBNondiabetic BBDiabetic groupEpinephrine responseNorepinephrine responseCatecholamine responsesIatrogenic hypoglycemiaDiabetic ratsGlucagon releaseEfferent pathwaysSympathoadrenal systemControl ratsHypoglycemic ratsHypoglycemiaGlucopeniaCounterregulationRatsHypothalamusPerfusionCritical role