2008
Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth
Shaw M, Savoye M, Cali A, Dziura J, Tamborlane WV, Caprio S. Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth. Diabetes Care 2008, 32: 45-47. PMID: 18840769, PMCID: PMC2606827, DOI: 10.2337/dc08-0808.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentBody Mass IndexChildFemaleGlucose Tolerance TestHumansInsulinLife StyleMaleObesityWeight LossConceptsIntensive lifestyle programLifestyle programInsulin sensitivityObese youthBody fatGlucose metabolismLarge randomized clinical trialsOral glucose tolerance testGlucose tolerance testRandomized clinical trialsGlucose toleranceObese childrenControl subjectsTolerance testClinical trialsBody compositionBody weightSubject changesGreater decreaseSubjectsFatMetabolismBMIResearch designBright bodies
2006
Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S. Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4287-4294. PMID: 16912127, DOI: 10.1210/jc.2006-1010.Peer-Reviewed Original ResearchConceptsIntrahepatic fat accumulationAlanine aminotransferase levelsHepatic fat fractionVisceral fatInsulin sensitivityMagnetic resonance imagingFat accumulationAminotransferase levelsMetabolic syndromeFatty liverInsulin resistanceChildhood obesityResonance imagingLipid metabolismNonalcoholic fatty liver diseaseHispanic race/ethnicityAbdominal fat partitioningSerum aminotransferase elevationFatty liver diseaseBiomarkers of inflammationHepatic fat accumulationReduced insulin sensitivityFat fractionRace/ethnicityAminotransferase elevation
2003
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentrationDefective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia
Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS. Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 1503-1511. PMID: 12679430, DOI: 10.1210/jc.2002-021013.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdrenergic beta-AgonistsAdultBlood GlucoseDiabetes Mellitus, Type 1EpinephrineFatty Acids, NonesterifiedFemaleGlucoseGlucose Clamp TechniqueGlycerolHomeostasisHumansHypoglycemiaInsulinLactic AcidLipolysisMaleMuscle, SkeletalNorepinephrineReceptors, Adrenergic, beta-2TerbutalineConceptsT1DM patientsControl subjectsGlucose disposalAdipose tissueType 1 diabetes mellitus patientsWhole-body glucose disposalWhole-body glucose useSkeletal muscleDiabetes mellitus patientsGlucagon secretory responsesRisk of hypoglycemiaPlasma epinephrine concentrationSeverity of hypoglycemiaAdipose tissue lipolysisMajor target tissuesHyperinsulinemic euglycemiaAgonist terbutalineAdrenomedullary responseMellitus patientsNondiabetic subjectsDeficient releasePlasma epinephrinePlasma glucoseInsulin infusionCatecholamine secretion
2000
Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.
Enoksson S, Talbot M, Rife F, Tamborlane WV, Sherwin RS, Caprio S. Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls. Diabetes 2000, 49: 2149-2153. PMID: 11118019, DOI: 10.2337/diabetes.49.12.2149.Peer-Reviewed Original ResearchConceptsSubcutaneous abdominal adipose tissueAbdominal adipose tissueBeta2-adrenergic agonistObese adolescent girlsGlycerol releaseAdipose tissueBMI 21Lean girlsObese womenObese girlsSelective beta2-adrenergic agonistAdolescent girlsSignificant differencesMobilization of fatBMI 36Lean womenAdrenergic systemLipolytic sensitivityAdolescent obesityLipolytic effectVivo stimulationBMI 38AgonistsWomenObesity
1996
Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations
Caprio S, Tamborlane WV, Silver D, Robinson C, Leibel R, McCarthy S, Grozman A, Belous A, Maggs D, Sherwin RS. Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations. American Journal Of Physiology 1996, 271: e626-e630. PMID: 8843759, DOI: 10.1152/ajpendo.1996.271.3.e626.Peer-Reviewed Original ResearchConceptsVisceral fat massLeptin levelsLeptin concentrationsFat depotsJuvenile obesityFat massInsulin concentrationsDb/db miceHyperglycemic clamp studiesAdult obese subjectsOb gene productDevelopment of obesityFa/fa ratsLeptin mRNA expressionSubcutaneous fat depotsMagnetic resonance imagingSpecific fat depotsObese subjectsNonobese subjectsObese childrenDb miceNonobese childrenAcute increaseObese stateHyperinsulinemic conditions
1995
Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle.
Maggs DG, Jacob R, Rife F, Lange R, Leone P, During MJ, Tamborlane WV, Sherwin RS. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. Journal Of Clinical Investigation 1995, 96: 370-377. PMID: 7615807, PMCID: PMC185209, DOI: 10.1172/jci118043.Peer-Reviewed Original ResearchConceptsAdipose tissueEuglycemic hyperinsulinemiaInterstitial glucoseSkeletal muscleInterstitial glycerol concentrationsInterstitial fluid concentrationsHuman skeletal muscleHuman quadriceps muscleInterstitial glycerolIntramuscular lipolysisReuptake blockadePlasma levelsPeripheral tissuesQuadriceps musclePlasma glycerolAlanine levelsFuel metabolismFluid concentrationsMuscleHyperinsulinemiaMetabolic fuelsHuman subjectsSimilar changesHigh rateTissueCentral adiposity and its metabolic correlates in obese adolescent girls
Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV. Central adiposity and its metabolic correlates in obese adolescent girls. American Journal Of Physiology 1995, 269: e118-e126. PMID: 7631766, DOI: 10.1152/ajpendo.1995.269.1.e118.Peer-Reviewed Original ResearchConceptsObese adolescent girlsObese girlsInsulin secretionInsulin actionSubcutaneous abdominal fat depotsFree fatty acid levelsGlucose-stimulated insulin responseHip circumference ratioEuglycemic insulin clampHyperglycemic clamp techniqueBasal insulin secretionAbdominal fat depotsAdolescent girlsHepatic glucose productionFatty acid levelsMagnetic resonance imagingLean womenCentral adiposityInsulin dosesVisceral fatInsulin clampInsulin resistanceNonobese girlsGlucose disposalInsulin infusion