2006
Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2004
Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
1991
Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
AMIEL S, CAPRIO S, SHERWIN R, PLEWE G, HAYMOND M, TAMBORLANE W. Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 277-282. PMID: 1991798, DOI: 10.1210/jcem-72-2-277.Peer-Reviewed Original ResearchConceptsPeripheral glucose metabolismInsulin resistancePubertal childrenGlucose metabolismHigher insulin doseMU/m2Hyperglycemic clamp studiesEuglycemic insulin clampEnhanced insulin responseHepatic glucose productionSelective insulin resistanceChain amino acidsHealthy prepubertalCompensatory hyperinsulinemiaInsulin doseInsulin clampPeripheral glucoseInsulin responsePlasma levelsPrepubertal childrenClamp studiesProtein anabolismNormal pubertyGlucose productionAmino acid metabolism