1994
Metabolic Effects of rhIGF-1 in Normal Human Subjects
Rennert NJ, Boulware SD, Kerr D, Caprio S, Tamborlane WV, Sherwin RS. Metabolic Effects of rhIGF-1 in Normal Human Subjects. Advances In Experimental Medicine And Biology 1994, 343: 311-318. PMID: 8184741, DOI: 10.1007/978-1-4615-2988-0_30.Peer-Reviewed Original ResearchConceptsRhIGF-1Hepatic glucose productionIGF-1Free fatty acidsGlucose productionGlucose uptakeEuglycemic clamp techniqueHuman IGF-1Normal human subjectsSpite of maintenanceSustained euglycemiaMetabolic effectsFFA levelsHypoglycemic effectClamp techniqueMetabolic actionsProfound reductionInsulinHypoglycemic hormoneFat cellsRatsComparable stimulationProtein breakdownSimilar extentEuglycemia
1993
Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin.
Kerr D, Tamborlane WV, Rife F, Sherwin RS. Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin. Journal Of Clinical Investigation 1993, 91: 141-147. PMID: 8423214, PMCID: PMC330007, DOI: 10.1172/jci116163.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factor-1Insulin-like growth factor-1Growth factor-1Glucagon responseGlucose productionAbsent glucagon responsesPlasma glucose nadirsGrowth hormone responseInsulin-induced hypoglycemiaAwareness of hypoglycemiaGrowth hormone releaseFactor 1Hepatic glucose productionHuman insulin-like growth factor-1Recognition of hypoglycemiaSymptomatic awarenessNorepinephrine levelsCounterregulatory responsesHypoglycemic stimulusSympathetic activityGlucose nadirsGlucagon releaseBlood glucoseRebound increaseHormone release
1992
Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects
Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 1076-1080. PMID: 1400874, DOI: 10.1210/jcem.75.4.1400874.Peer-Reviewed Original ResearchConceptsType I diabetic subjectsHepatic glucose productionDiabetic subjectsGlucose productionControl subjectsInsulin-dependent diabetic subjectsDefective glucose counterregulationFailure of gluconeogenesisLow-dose infusionInsulin-induced hypoglycemiaInsulin-dependent diabetesNormal control subjectsGlucagon responseGlucose counterregulationIDDM patientsIDDM subjectsDose infusionEpinephrine releaseInsulin levelsPlasma glucoseImpaired stimulationConversion of alanineNormal subjectsCompensatory stimulationHepatic response
1991
Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects
Caprio S, Gerety G, Tamborlane WV, Jones T, Diamond M, Jacob R, Sherwin RS. Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects. American Journal Of Physiology 1991, 260: e852-e858. PMID: 2058661, DOI: 10.1152/ajpendo.1991.260.6.e852.Peer-Reviewed Original ResearchConceptsInsulin-induced hypoglycemiaGlucose counterregulationIDDM patientsGlucose productionOpiate blockadeHormonal responsesInsulin-dependent diabetic subjectsCounterregulatory hormone releaseDefective glucose counterregulationInsulin clamp studiesAbsence of hypoglycemiaInsulin-dependent patientsVariable glucose infusionDefective counterregulationHypoglycemic counterregulationNaloxone studyGlucagon responseDiabetic subjectsEndogenous opiatesGlucoregulatory hormonesGlucoregulatory responsesHormone releaseGlucose infusionHealthy subjectsCortisol releaseMetabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats
Jacob RJ, Sherwin RS, Bowen L, Fryburg D, Fagin KD, Tamborlane WV, Shulman GI. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats. American Journal Of Physiology 1991, 260: e262-e268. PMID: 1996629, DOI: 10.1152/ajpendo.1991.260.2.e262.Peer-Reviewed Original ResearchConceptsBB/W ratsBeta-hydroxybutyrate levelsDiabetic ratsNondiabetic ratsGlucose uptakeW ratsDiabetic BB/W ratsGlucose productionInsulin-like growth factor IIGF-I infusionDiabetic BB ratsInsulin-dependent diabetesMetabolic responseGrowth factor IHepatic glucose productionInsulin-stimulated glucose uptakeGlucose production rateBB ratsMetabolic effectsSimilar twofold increaseIGFRatsFactor IInsulinKetone concentrationsInsulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
AMIEL S, CAPRIO S, SHERWIN R, PLEWE G, HAYMOND M, TAMBORLANE W. Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 277-282. PMID: 1991798, DOI: 10.1210/jcem-72-2-277.Peer-Reviewed Original ResearchConceptsPeripheral glucose metabolismInsulin resistancePubertal childrenGlucose metabolismHigher insulin doseMU/m2Hyperglycemic clamp studiesEuglycemic insulin clampEnhanced insulin responseHepatic glucose productionSelective insulin resistanceChain amino acidsHealthy prepubertalCompensatory hyperinsulinemiaInsulin doseInsulin clampPeripheral glucoseInsulin responsePlasma levelsPrepubertal childrenClamp studiesProtein anabolismNormal pubertyGlucose productionAmino acid metabolism
1989
Oxidative fuel metabolism during mild hypoglycemia: critical role of free fatty acids
Caprio S, Gelfand RA, Tamborlane WV, Sherwin RS. Oxidative fuel metabolism during mild hypoglycemia: critical role of free fatty acids. American Journal Of Physiology 1989, 256: e413-e419. PMID: 2646946, DOI: 10.1152/ajpendo.1989.256.3.e413.Peer-Reviewed Original ResearchConceptsFree fatty acidsCarbohydrate oxidationFuel metabolismGlucose uptakeInsulin-induced fallInsulin-induced hypoglycemiaFatty acidsMild hypoglycemiaCatecholamine releaseMild hyperinsulinemiaAddition of heparinNormal subjectsFat oxidationTransient decreaseGlucose productionGroup of studiesHypoglycemiaInsulinPropranololEarly riseHeparinGlucose concentrationBase lineMetabolismLatter changes