2014
Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验
Tamborlane WV, Renard E, Wadwa RP, Blevins T, Jacober SJ, Liu R, D'Souza DN, Rees TM. Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验. Journal Of Diabetes 2014, 7: 270-278. PMID: 24734891, DOI: 10.1111/1753-0407.12162.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood Glucose Self-MonitoringChinaCross-Over StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Double-Blind MethodFemaleFollow-Up StudiesHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsInsulin AspartInsulin Infusion SystemsInsulin LisproMalePostprandial PeriodPrognosisRisk FactorsConceptsContinuous subcutaneous insulin infusionSelf-monitoring blood glucoseTreatment periodCross-over designBlood glucoseDay 6Insulin aspartInsulin lisproMean total daily insulin doseTotal daily insulin doseTotal hypoglycemia rateDaily insulin dosePrimary efficacy measureType 1 DMMean blood glucoseSubcutaneous insulin infusionType 1 diabetesHypoglycemia ratesInsulin doseRandomized trialsEfficacy measuresSMBG profilesInsulin infusionDay 1Two-treatmentInsulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy
Blackman SM, Raghinaru D, Adi S, Simmons JH, Ebner‐Lyon L, Chase HP, Tamborlane WV, Schatz DA, Block JM, Litton JC, Raman V, Foster NC, Kollman CR, DuBose SN, Miller KM, Beck RW, DiMeglio LA. Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy. Pediatric Diabetes 2014, 15: 564-572. PMID: 24494980, DOI: 10.1111/pedi.12121.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionT1D Exchange Clinic RegistryCross-sectional studyInjection usersClinic registryInitiation of CSIIUse of CSIIInsulin pumpLower hemoglobin A1c levelsDiabetic ketoacidosis eventsHemoglobin A1c levelsSevere hypoglycemia eventsSubcutaneous insulin infusionRetrospective longitudinal studyType 1 diabetesRisk of DKALongitudinal studyYounger age groupsYoung childrenRace/ethnicityKetoacidosis eventsAnnual household incomeT1D durationA1c levelsHemoglobin A1c
2010
STAR 3 Randomized Controlled Trial to Compare Sensor-Augmented Insulin Pump Therapy with Multiple Daily Injections in the Treatment of Type 1 Diabetes: Research Design, Methods, and Baseline Characteristics of Enrolled Subjects
Davis SN, Horton ES, Battelino T, Rubin RR, Schulman KA, Tamborlane WV. STAR 3 Randomized Controlled Trial to Compare Sensor-Augmented Insulin Pump Therapy with Multiple Daily Injections in the Treatment of Type 1 Diabetes: Research Design, Methods, and Baseline Characteristics of Enrolled Subjects. Diabetes Technology & Therapeutics 2010, 12: 249-255. PMID: 20210562, PMCID: PMC2883476, DOI: 10.1089/dia.2009.0145.Peer-Reviewed Original ResearchConceptsMultiple daily injectionsContinuous subcutaneous insulin infusionType 1 diabetesPercentage of subjectsPump therapyEnd pointBaseline characteristicsDaily injectionsKey safety end pointsType 1Sensor-Augmented Pump TherapyReal-time continuous glucose monitoringSensor-Augmented Insulin Pump TherapyNormal glycemic rangeTertiary end pointPrimary end pointSafety end pointSecondary end pointsInsulin pump therapySubcutaneous insulin infusionYears of treatmentContinuous glucose monitoringMDI cohortSevere hypoglycemiaClinical outcomes
2009
From pumps to prevention: recent advances in the treatment of type 1 diabetes
Sherr J, Cengiz E, Tamborlane WV. From pumps to prevention: recent advances in the treatment of type 1 diabetes. Drug Discovery Today 2009, 14: 973-981. PMID: 19580883, DOI: 10.1016/j.drudis.2009.06.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityBiosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1Drug Therapy, CombinationGlycated HemoglobinHumansHypoglycemic AgentsImmunologic FactorsInfusion PumpsInsulinInsulin-Secreting CellsPancreas, ArtificialPrimary PreventionTreatment OutcomeConceptsContinuous subcutaneous insulin infusionContinuous glucose monitoringType 1 diabetes mellitusBeta-cell destructionRapid-acting insulinSubcutaneous insulin infusionTreatment of T1DMType 1 diabetesBlood glucose fluctuationsImproved insulin deliveryAutoimmune processDiabetes mellitusPediatric patientsSecondary interventionsTreatment optionsInsulin infusionNew medicationsGlucose fluctuationsGlucose monitoringInsulin deliveryArtificial pancreasPreventionTreatmentInitial studyMellitus
2008
Past, present, and future of insulin pump therapy: better shot at diabetes control
Sherr J, Tamborlane WV. Past, present, and future of insulin pump therapy: better shot at diabetes control. Annals Of Global Health 2008, 75: 352-361. PMID: 18729180, PMCID: PMC2562271, DOI: 10.1002/msj.20055.Peer-Reviewed Original ResearchConceptsPump therapyDiabetes controlContinuous subcutaneous insulin infusion (CSII) therapySubcutaneous insulin infusion therapyContinuous subcutaneous insulin infusionInsulin pump therapyInsulin infusion therapySubcutaneous insulin infusionType 1 diabetesComplications TrialInfusion therapyInsulin infusionIntensive treatmentPump useTherapyArtificial pancreasContinuous glucose sensorsDelivery systemFindingsSelection criteriaPatientsDiabetesInfusionPancreasNew findings
2006
Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes
Tamborlane WV, Sikes KA, Steffen AT, Weinzimer SA. Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes. Diabetes Research And Clinical Practice 2006, 74: s112-s115. PMID: 17182301, DOI: 10.1016/s0168-8227(06)70011-0.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionSubcutaneous insulin infusionType 1 diabetesInsulin infusionEfficacy of CSIIExcessive weight gainInsulin pump therapyNew insulin analoguesQuality of lifePediatric patientsSevere hypoglycemiaHemoglobin levelsPump therapyTreatment optionsClinical studiesInsulin analoguesWeight gainDiabetesInfusionChildrenRecent studiesSafetyHypoglycemiaPatientsTherapyThe renaissance of insulin pump treatment in childhood type 1 diabetes
Tamborlane WV, Swan K, Sikes KA, Steffen AT, Weinzimer SA. The renaissance of insulin pump treatment in childhood type 1 diabetes. Reviews In Endocrine And Metabolic Disorders 2006, 7: 205-213. PMID: 17160722, DOI: 10.1007/s11154-006-9018-9.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionQuality of lifePump therapyEfficacy of CSIINormal blood sugar levelsType 1 diabetes mellitusChildhood type 1 diabetesRisk of hypoglycemiaInsulin pump therapyBlood sugar levelsSubcutaneous insulin infusionType 1 diabetesNew insulin analoguesTreatment of childrenMacrovascular complicationsDiabetes mellitusPediatric patientsSevere hypoglycemiaHemoglobin levelsPatient selectionTreatment optionsInsulin infusionClinical studiesAge of childrenInsulin analogues
2005
Insulin Pump Treatment of Childhood Type 1 Diabetes
Weinzimer SA, Sikes KA, Steffen AT, Tamborlane WV. Insulin Pump Treatment of Childhood Type 1 Diabetes. Pediatric Clinics Of North America 2005, 52: 1677-1688. PMID: 16301088, DOI: 10.1016/j.pcl.2005.07.004.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionQuality of lifeLong-term microvascular complicationsEfficacy of CSIINormal blood sugar levelsType 1 diabetes mellitusInsulin pump treatmentChildhood Type 1Risk of hypoglycemiaBlood sugar levelsSubcutaneous insulin infusionNew insulin analoguesTreatment of childrenMicrovascular complicationsDiabetes mellitusPump treatmentSevere hypoglycemiaHemoglobin levelsTreatment optionsInsulin infusionClinical studiesAge of childrenInsulin analoguesType 1Weight gainContrasting Challenges of Insulin Pump Therapy in a Toddler and Adolescent With Type 1 Diabetes
Doyle Boland EA, Steffen AT, Tamborlane WV. Contrasting Challenges of Insulin Pump Therapy in a Toddler and Adolescent With Type 1 Diabetes. The Science Of Diabetes Self-Management And Care 2005, 31: 584-590. PMID: 16100334, DOI: 10.1177/0145721705278888.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionType 1 diabetesGlycemic controlCSII therapyHypoglycemic episodesInsulin bolus dosesHemoglobin A1c levelsPediatric diabetes clinicSevere hypoglycemic episodesInsulin pump therapySubcutaneous insulin infusionYears of ageAge 13 yearsA1c levelsCatheter siteDiabetes clinicBolus dosesPump therapyDaily injectionsIdeal therapyInsulin infusionInsulin injectionsPostprandial hyperglycemiaFood intakePump useDisease Management in the Young Diabetic Patient: Glucose Monitoring, Coping Skills, and Treatment Strategies
Weinzimer SA, Doyle EA, Tamborlane WV. Disease Management in the Young Diabetic Patient: Glucose Monitoring, Coping Skills, and Treatment Strategies. Clinical Pediatrics 2005, 44: 393-403. PMID: 15965545, DOI: 10.1177/000992280504400503.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAdultAge FactorsAgedAttitude to HealthBlood GlucoseBlood Glucose Self-MonitoringChildDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsInjections, SubcutaneousInsulinInsulin ResistanceMaleMiddle AgedPatient CompliancePatient Education as TopicPrognosisRisk AssessmentSeverity of Illness IndexTreatment OutcomeConceptsYoung diabetic patientsGlycemic controlDiabetic patientsType 1 diabetes mellitusContinuous subcutaneous insulin infusionPresence of hypoglycemiaSubcutaneous insulin infusionType 2 diabetesDisease managementContinuous glucose-monitoring systemPositive treatment outcomesGlucose-monitoring systemInsulin glargineYounger patientsDiabetes mellitusHypoglycemic episodesJuvenile patientsNocturnal hypoglycemiaInsulin infusionTreatment outcomesTreatment strategiesCareful monitoringDiabetesPatientsGlucose monitoring
2004
Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report
Weinzimer SA, Ahern JH, Doyle EA, Vincent MR, Dziura J, Steffen AT, Tamborlane WV. Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report. Pediatrics 2004, 114: 1601-1605. PMID: 15574621, DOI: 10.1542/peds.2004-0092.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionType 1 diabetesMultiple daily injectionsSubcutaneous insulin infusionSevere hypoglycemiaDaily injectionsInsulin infusionRate of SHMonths of CSIIYoung childrenEpisodes of DKAOlder pediatric patientsVery Young ChildrenPersistence of benefitHypoglycemia frequencyYounger patientsGlycemic controlPediatric patientsPump treatmentClinic databaseSafety dataEmergency treatmentAge groupsType 1DiabetesA Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine
Doyle (Boland) E, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV. A Randomized, Prospective Trial Comparing the Efficacy of Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections Using Insulin Glargine. Diabetes Care 2004, 27: 1554-1558. PMID: 15220227, DOI: 10.2337/diacare.27.7.1554.Peer-Reviewed Original ResearchConceptsTotal daily insulin doseMultiple daily injectionsType 1 diabetesWeeks of therapyGlargine groupDaily injectionsInsulin aspartMDI treatmentShort-term studiesContinuous subcutaneous insulin infusion (CSII) therapySubcutaneous insulin infusion therapyContinuous subcutaneous insulin infusionSelf-monitoring blood glucoseDaily insulin doseSelf-monitored blood glucose measurementsInsulin infusion therapySubcutaneous insulin infusionBlood glucose readingsSelf-monitored blood glucose readingsBlood glucose measurementsDaily glargineCSII groupDose titrationProspective trialAdverse eventsRediscovery of insulin pump treatment of childhood type 1 diabetes.
Weinzimer SA, Doyle EA, Steffen AT, Sikes KA, Tamborlane WV. Rediscovery of insulin pump treatment of childhood type 1 diabetes. Minerva Medica 2004, 95: 85-92. PMID: 15272243.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionInsulin pump therapyQuality of lifeSevere hypoglycemiaPump therapyLong-term microvascular complicationsEfficacy of CSIIType 1 diabetes mellitusWeight gainChildhood type 1 diabetesExcessive weight gainBasal infusion rateSubcutaneous insulin infusionType 1 diabetesNew insulin analoguesTreatment of childrenContinuous glucose monitoringMicrovascular complicationsDiabetes mellitusPediatric patientsHemoglobin levelsNocturnal hypoglycemiaTreatment optionsNormal glycemiaInsulin infusion
2003
Insulin Pump Therapy in Childhood Diabetes Mellitus
Tamborlane WV, Fredrickson LP, Ahern JH. Insulin Pump Therapy in Childhood Diabetes Mellitus. Treatments In Endocrinology 2003, 2: 11-21. PMID: 15871551, DOI: 10.2165/00024677-200302010-00002.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionSevere hypoglycemiaEffectiveness of CSIIType 1 diabetes mellitusRapid-acting insulin analoguesDevelopment of ketoacidosisNear-normal glycemiaOvernight glycemic controlProgrammable basal ratesExcessive weight gainSelection of patientsExercise-induced hypoglycemiaInitiation of treatmentInsulin pump therapySubcutaneous insulin infusionBlood glucose levelsTiming of mealsQuality of lifeContinuous glucose monitoringCare of childrenBolus capabilitiesPediatrie patientsDiabetic ketoacidosisVascular complicationsDiabetes mellitus