2000
Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications
Gratton J, Fontana J, Sessa W. Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications. 2000, 157-166. DOI: 10.1016/b978-012370420-7/50010-1.Peer-Reviewed Original ResearchNitric oxideEndothelial NOSVascular remodelingEndothelium-derived relaxing factorsEndothelium-derived nitric oxideEndothelial nitric oxide synthase regulationBlood pressure controlNitric oxide synthase regulationRelaxing factorsVasomotor controlCardiovascular homeostasisNOS isoformsVascular endotheliumVascular biologyNOS regulationPhysiological productionPosttranslational control mechanismsFamily membersAngiogenesisProfound perturbationRemodelingPosttranslational modificationsMolecular controlThrombosisInflammation
1991
The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen
Hecker M, Sessa W, Mitchell J, Änggård E, Vane J. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen. Journal Of Cardiovascular Pharmacology 1991, 17: s19-s24. DOI: 10.1097/00005344-199117003-00005.Peer-Reviewed Original ResearchCultured endothelial cellsBiosynthesis of EDRFRelease of EDRFEndothelial cellsNitric oxideKrebs solutionComplete urea cycleImportant regulatory factorCellular regulationExcess nitrogenVariety of cellsRegulatory factorsBiosynthesisPhysiologic buffer solutionFlow-induced releaseRelaxing factorsCytotoxic macrophagesIntracellular sourcesBrain synaptosomesEDRF biosynthesisEDRFIntracellular concentrationTransient riseCalcium ionophoreGln