2021
Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis
Li X, Zhu X, Wu H, Van Dyke T, Xu X, Morgan E, Fu W, Liu C, Tu Q, Huang D, Chen J. Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis. Frontiers In Cell And Developmental Biology 2021, 9: 703670. PMID: 34650969, PMCID: PMC8509718, DOI: 10.3389/fcell.2021.703670.Peer-Reviewed Original ResearchMechanisms of irisinOA progressionKI miceKO miceOA mouse modelIntra-articular injectionNovel therapeutic targetPrimary chondrocytesPathological tissue samplesInflammatory factorsOA pathogenesisPathological featuresIntraarticular injectionInflammatory conditionsOA tissuesOsteoarthritis pathophysiologySevere OAIrisinJoint tissuesMouse modelCartilage degradationKnockout miceTherapeutic targetCartilage developmentTherapeutic potential
2016
Foxo4‐ and Stat3‐dependent IL‐10 production by progranulin in regulatory T cells restrains inflammatory arthritis
Fu W, Hu W, Shi L, Mundra J, Xiao G, Dustin M, Liu C. Foxo4‐ and Stat3‐dependent IL‐10 production by progranulin in regulatory T cells restrains inflammatory arthritis. The FASEB Journal 2016, 31: 1354-1367. PMID: 28011648, PMCID: PMC5349791, DOI: 10.1096/fj.201601134r.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCell Cycle ProteinsCells, CulturedForkhead Transcription FactorsGranulinsIntercellular Signaling Peptides and ProteinsInterleukin-10MAP Kinase Signaling SystemMiceMice, Inbred DBAPhosphatidylinositol 3-KinasesProgranulinsSTAT3 Transcription FactorT-Lymphocytes, RegulatoryConceptsIL-10 productionRegulatory T cellsInflammatory arthritisIL-10T cellsAnti-inflammatory cytokine IL-10Forkhead box protein O4PI3K pathwayCollagen-induced arthritisCytokine IL-10Green fluorescent protein reporter miceTranscription factorsSequencing screenSignal transducerJNK signalingTranscription 3K pathwayImmunological mechanismsAutoimmune diseasesInflammatory conditionsMouse modelArthritisPresent new insightsReporter miceProgranulin