2018
B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells
Yu W, Chen L, Guo S, Luo L, Chen L. B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells. OncoImmunology 2018, 7: e1504156. PMID: 30574431, PMCID: PMC6298416, DOI: 10.1080/2162402x.2018.1504156.Peer-Reviewed Original ResearchAllogeneic T cellsT cellsB7-H1Systemic inflammationPD-1B7-H1 monoclonal antibodyB7-H1/PDAllogeneic T-cell responsesB7-H1 mAbProgression of GVHDT cell responsesCo-inhibitory pathwaysT-cell lysisLong-term toleranceHost cell destructionNormal hematopoietic cellsDisseminated inflammationHost diseaseLeukemia responseAccelerated progressionMouse modelCell destructionInflammationMonoclonal antibodiesTypes of cellsB7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction
Chen L, Azuma T, Yu W, Zheng X, Luo L, Chen L. B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3126-3131. PMID: 29507197, PMCID: PMC5866601, DOI: 10.1073/pnas.1722043115.Peer-Reviewed Original ResearchConceptsB7-H1 expressionDendritic cellsT cell responsesB7-H1CTL responsesTumor escapeB7-H1/PDCell responsesSubdominant T-cell responsesPolyclonal T cell responsesCombination cancer immunotherapyDifferent dendritic cellsAdaptive resistanceT lymphocyte destructionAdvanced human cancersMurine tumor modelsSurvival benefitTumor AgDominant AgAntibody blockadeCancer immunotherapyDC functionImmune destructionLymphocyte destructionT lymphocytes
2017
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb
Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2017, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.Peer-Reviewed Original ResearchConceptsRepulsive guidance molecule bT cell responsesB7-DCPD-1T cellsB7-DC/PDCoinhibitory receptor PD-1T helper 1 responseTh2-mediated asthmaSmall airway inflammationReceptor PD-1T cell inhibitionExperimental mouse modelNaive mouse T cellsMouse T cellsAirway inflammationTh1 polarizationTh1 responseDendritic cellsLung pathologyMouse modelCostimulatory functionCostimulatory receptorsCD4Costimulation