2024
Early thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flow
Bai H, Li Z, Zhang W, Thaxton C, Ohashi Y, Gonzalez L, Kano M, Yatsula B, Hwa J, Dardik A. Early thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flow. Journal Of Thrombosis And Haemostasis 2024 PMID: 39173878, DOI: 10.1016/j.jtha.2024.07.028.Peer-Reviewed Original ResearchEndothelial cell lossArteriovenous fistulaSmooth muscle cellsNeointimal hyperplasiaHeterogeneous neointimaCell lossThrombus formationMT/mG reporter miceHuman arteriovenous fistulaeInhibit neointimal hyperplasiaEarly thrombus formationAntiplatelet therapyC57BL/6 miceReporter miceAVF failureWistar ratsVenous systemJuxta-anastomotic areaMuscle cellsAnimal modelsVenous outflowEarly thrombusEndothelial cellsArterial inflowThrombusDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, PMCID: PMC11380968, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2023
Empagliflozin inhibits neointimal hyperplasia through attenuating endothelial-to-mesenchymal transition via TAK-1/NF-κB pathway
Zhang W, Li X, Li M, He H, Yang C, Wang M, Liu D, Zhang L, Shu C. Empagliflozin inhibits neointimal hyperplasia through attenuating endothelial-to-mesenchymal transition via TAK-1/NF-κB pathway. European Journal Of Pharmacology 2023, 954: 175826. PMID: 37321472, DOI: 10.1016/j.ejphar.2023.175826.Peer-Reviewed Original ResearchConceptsNeointimal hyperplasiaEmpagliflozin treatmentTreatment groupsControl groupExpression levelsFSP-1NF-κB expression levelsTAK-1Western blottingCarotid ligation injuryInflammation-induced EndMTKi-67-positive cellsP-NF-κBMale C57BL/6J miceInhibits Neointimal HyperplasiaVascular neointimal hyperplasiaInflammatory gene mRNA expressionNF-κB pathwayNF-κB signalingMRNA expression levelsGene mRNA expressionVehicle treatmentArtery ligationLigation injuryInflammatory cellsSulfasalazine induces autophagy inhibiting neointimal hyperplasia following carotid artery injuries in mice
Zhang W, Yan C, Xiao Y, Sun Y, Lin Y, Li Q, Cai W. Sulfasalazine induces autophagy inhibiting neointimal hyperplasia following carotid artery injuries in mice. Frontiers In Bioengineering And Biotechnology 2023, 11: 1199785. PMID: 37288359, PMCID: PMC10242098, DOI: 10.3389/fbioe.2023.1199785.Peer-Reviewed Original ResearchVascular smooth muscle cellsNeointimal hyperplasiaTreatment groupsSmooth muscle cellsLigation injurySSZ groupWestern blottingControl groupMuscle cellsExpression levelsVascular smooth muscle cell proliferationLC3-IILC3-II expression levelsCarotid ligation injurySmooth muscle cell proliferationCarotid artery injuryCell nuclear antigen expressionPrevention of restenosisRatio of intimaCell proliferationMuscle cell proliferationP62 protein expressionNuclear antigen expressionPhosphorylation of mTORArtery injury
2021
Roles of MicroRNAs in Peripheral Artery In‐Stent Restenosis after Endovascular Treatment
Wang M, Zhang W, Zhang L, Wang L, Li J, Shu C, Li X. Roles of MicroRNAs in Peripheral Artery In‐Stent Restenosis after Endovascular Treatment. BioMed Research International 2021, 2021: 9935671. PMID: 34368362, PMCID: PMC8337102, DOI: 10.1155/2021/9935671.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal angioplastyEndovascular repairStent restenosisPeripheral arterial diseaseNovel therapeutic targetPotential therapeutic strategyMajor pathological processesTransluminal angioplastyArterial diseaseEndovascular treatmentLimited complicationsPeripheral arteriesStent implantationEndothelial denudationInflammatory responseClinical studiesNeointimal hyperplasiaTherapeutic strategiesRole of microRNAsTherapeutic targetRestenosisPathological processesLong-term successRole of miRNAsUnderlying mechanism