2015
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection
Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science 2015, 350: 563-567. PMID: 26429886, PMCID: PMC4651917, DOI: 10.1126/science.aab2749.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLymph nodesMurine leukemia virusCD169/SiglecSecondary lymphoid tissuesPermissive lymphocytesDendritic cellsImmunodeficiency virusSynaptic contactsLymphoid tissueRobust infectionVirological synapsesI-type lectinsRetroviral spreadViral spreadUninfected cellsInfectionLeukemia virusVirusMacrophagesCellsRetrovirusesCell-cell contactCD169Lymphocytes
2013
Cell-to-Cell Transmission of HIV
Agosto L, Zhong P, Mothes W. Cell-to-Cell Transmission of HIV. 2013, 167-184. DOI: 10.1007/978-1-4614-7729-7_7.Peer-Reviewed Original ResearchCell-free virusAnti-retroviral therapyCell-free HIVCell transmissionHIV/AIDSHIV cellDifferent lymphocytesVirological synapseVirological synapsesHIVCell-free spreadImmunological synapsesTarget cellsRestriction factorsHIV assemblySynapsesVirusCellsCell-cell contactSynapse modelLymphocytesPathogenesisTherapyAIDSAntibodies