2024
Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2023
A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association
Ndumele C, Neeland I, Tuttle K, Chow S, Mathew R, Khan S, Coresh J, Baker-Smith C, Carnethon M, Després J, Ho J, Joseph J, Kernan W, Khera A, Kosiborod M, Lekavich C, Lewis E, Lo K, Ozkan B, Palaniappan L, Patel S, Pencina M, Powell-Wiley T, Sperling L, Virani S, Wright J, Singh R, Elkind M, Rangaswami J, Association O. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 1636-1664. PMID: 37807920, DOI: 10.1161/cir.0000000000001186.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseMetabolic risk factorsMetabolic syndromeRisk factorsKidney diseaseCardiovascular diseaseSocial determinantsEarly life preventionUnique management considerationsManagement of patientsInterdisciplinary care modelAmerican Heart AssociationBiological risk factorsScientific statementKidney outcomesLifestyle modificationHeart AssociationClinical managementCare modelClinical careSyndromeClinical phenotypeDiseaseMajor guidelinesWeight lossCardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association
Ndumele C, Rangaswami J, Chow S, Neeland I, Tuttle K, Khan S, Coresh J, Mathew R, Baker-Smith C, Carnethon M, Despres J, Ho J, Joseph J, Kernan W, Khera A, Kosiborod M, Lekavich C, Lewis E, Lo K, Ozkan B, Palaniappan L, Patel S, Pencina M, Powell-Wiley T, Sperling L, Virani S, Wright J, Singh R, Elkind M, Association O. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation 2023, 148: 1606-1635. PMID: 37807924, DOI: 10.1161/cir.0000000000001184.Peer-Reviewed Original ResearchConceptsMetabolic risk factorsMetabolic healthMetabolic syndromeRisk factorsPresidential AdvisorySocial determinantsCardiovascular disease eventsChronic kidney diseaseAdverse social determinantsAmerican Heart AssociationSignificant clinical impactMetabolic stagingSubspecialty guidelinesCardiovascular mortalityCardioprotective effectsKidney functionKidney diseaseTherapeutic optionsHeart AssociationInterdisciplinary careCardiovascular diseaseClinical impactHigh prevalenceCare fragmentationCare modelSeparate But Not Equal? A Cross-Sectional Study of Segregation by Payor Mix in Academic Primary Care Clinics
Hassan S, Viscoli C, O’Connor P, Dugdale L, Sofair A, Fitz M, Richards B, Feiereisel K, Lee S, Ost S, Swails J, Fishman M, Kernan W. Separate But Not Equal? A Cross-Sectional Study of Segregation by Payor Mix in Academic Primary Care Clinics. Journal Of General Internal Medicine 2023, 38: 2318-2325. PMID: 36800147, PMCID: PMC10406732, DOI: 10.1007/s11606-023-08066-x.Peer-Reviewed Original ResearchMeSH KeywordsAmbulatory Care FacilitiesCross-Sectional StudiesHumansInsurance, HealthMedicaidPrimary Health CareUnited StatesConceptsProportion of patientsUS academic health centersPrimary care clinicsAcademic health centersCare clinicsLongitudinal carePrimary care internal medicine clinicsAcademic primary care clinicPre-specified secondary analysisInternal medicine clinicCross-sectional studyMore patientsMedicaid insuranceMedicine clinicHealth centersSeparate clinicsPatientsClinicResultsThirty-nineSecondary analysisClinic directorsPayor mixResident physiciansMedicaidNIH funding
2022
Caring for Patients With Diabetes in Stroke Neurology
Kernan W, Forman R, Inzucchi S. Caring for Patients With Diabetes in Stroke Neurology. Stroke 2022, 54: 894-904. PMID: 36541212, DOI: 10.1161/strokeaha.122.038163.Peer-Reviewed Original ResearchConceptsCerebral small vessel diseaseCoronary heart diseaseSmall vessel diseaseConsequence of diabetesNeurology cliniciansStroke neurologyPeripheral neuropathyRoutine careVessel diseaseHeart diseaseHeterogeneous diseasePerson's riskDiabetesDiseasePatientsBrainRiskHarmful effectsNephropathyNeuropathyMajor contributorRetinopathyWorld populationNeurologistsDementia
2021
Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association
Kernan WN, Viera AJ, Billinger SA, Bravata DM, Stark SL, Kasner SE, Kuritzky L, Towfighi A, Arteriosclerosis T. Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke 2021, 52: e558-e571. PMID: 34261351, DOI: 10.1161/str.0000000000000382.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmerican Heart AssociationHumansMiddle AgedPrimary Health CareStrokeUnited StatesConceptsRecurrent strokePoststroke carePrimary careAmerican Heart Association/American Stroke AssociationOngoing functional impairmentPatient-centered primary careAmerican Stroke AssociationHigh blood pressureEvidence-based carePrimary care practicesPrimary care teamsPatient-centered careQuality of lifePoststroke managementLifestyle modificationAdult patientsLate complicationsQuality improvement strategiesBlood pressureAtrial fibrillationCarotid stenosisStroke AssociationOngoing careRisk factorsCare team
2015
The Selling of Primary Care 2015
Kernan WN, Elnicki DM, Hauer KE. The Selling of Primary Care 2015. Journal Of General Internal Medicine 2015, 30: 1376-1380. PMID: 26173527, PMCID: PMC4539323, DOI: 10.1007/s11606-015-3364-9.Peer-Reviewed Original ResearchMeSH KeywordsCareer ChoiceEducation, Medical, UndergraduateHumansPhysiciansPrimary Health CareUnited StatesWorkforceConceptsMedical schoolsUndergraduate medical educationLearning environmentStudents' perceptionsTeaching environmentMore schoolsMedical educationMedical studentsCareer optionsAcademic health centersSchoolsPhysician shortagesSimplistic notionsEducationAbstractThe roleAdult primary careRisk-based contractsStudentsDiscussionCareerExcellencePerceptionOpportunitiesEnvironmentPrimary care
2014
Litigation Seeking Access to Data From Ongoing Clinical Trials: A Threat to Clinical Research
Kernan WN, Viscoli CM, Varughese MC. Litigation Seeking Access to Data From Ongoing Clinical Trials: A Threat to Clinical Research. JAMA Internal Medicine 2014, 174: 1502-1504. PMID: 25047222, PMCID: PMC5758866, DOI: 10.1001/jamainternmed.2014.3248.Peer-Reviewed Original ResearchGuidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 2014, 45: 2160-2236. PMID: 24788967, DOI: 10.1161/str.0000000000000024.Peer-Reviewed Original ResearchConceptsTransient ischemic attackEvidence-based recommendationsIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsAntiphospholipid antibody syndromeVenous sinus thrombosisPrevention of strokeAortic arch atherosclerosisSickle cell diseaseImplementation of guidelinesAntibody syndromeFuture strokeRecurrent strokeAnticoagulation therapyAntiplatelet therapyAntithrombotic therapySinus thrombosisIschemic strokeNoncardioembolic strokeSecondary preventionArterial dissectionHypercoagulable statePatent foramenIntracranial hemorrhage
2013
Use of Recruitment Networks in Randomized Trials
Kernan WN. Use of Recruitment Networks in Randomized Trials. Stroke 2013, 44: s119-s121. PMID: 23709705, DOI: 10.1161/strokeaha.111.000694.Peer-Reviewed Original Research
2011
Boosting enrolment in clinical trials: validation of a regional network model
Kernan W, Viscoli C, Brass L, Amatangelo M, Birch A, Clark W, Conwit R, Furie K, Gorman M, Pesapane B, Kleindorfer D, Lovejoy A, Osborne J, Silliman S, Zweifler R, Horwitz R. Boosting enrolment in clinical trials: validation of a regional network model. Clinical Trials 2011, 8: 645-653. PMID: 21824978, PMCID: PMC3852692, DOI: 10.1177/1740774511414925.Peer-Reviewed Original ResearchConceptsClinical trialsTransient ischemic attackNames of patientsEligible patientsIschemic attackStroke preventionDrug adherenceStroke therapyActive surveillanceAverage monthly rateHome visitsPatientsHospitalTrial researchParticipant costsOutreach NetworkMultiple hospitalsTrialsStudy intervalNational InstituteEnrollmentMonthly rateStrokeParticipantsReproducible methodAlmost Internists: Analysis of Students Who Considered Internal Medicine but Chose Other Fields
Durning SJ, Elnicki DM, Cruess DF, Reddy S, Kernan WN, Harrell HE, Schwartz MD, Fagan MJ, Battistone M, Hauer KE. Almost Internists: Analysis of Students Who Considered Internal Medicine but Chose Other Fields. Academic Medicine 2011, 86: 194-200. PMID: 21169784, DOI: 10.1097/acm.0b013e3182045ee5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceCareer ChoiceClinical ClerkshipCross-Sectional StudiesDelivery of Health CareEducation, Medical, UndergraduateFactor Analysis, StatisticalFemaleHumansInternal MedicineLogistic ModelsMaleSpecializationStudents, MedicalSurveys and QuestionnairesUnited StatesWorkforceConceptsEducational experienceCareer choiceCareer decisionsFourth-year medical studentsMedical student career choiceAnalysis of studentsNumber of studentsStudents' career choicesInternal medicineIM clerkshipStudent characteristicsMedical studentsU.S. institutionsStudentsIntellectual challengePatient's internistCareerAuthors' modelImportant underpinningExperienceChoosersPolicy makersSpecialtiesPercentage of varianceClerkship
2008
Factors Associated With Medical Students' Career Choices Regarding Internal Medicine
Hauer KE, Durning SJ, Kernan WN, Fagan MJ, Mintz M, O’Sullivan P, Battistone M, DeFer T, Elnicki M, Harrell H, Reddy S, Boscardin CK, Schwartz MD. Factors Associated With Medical Students' Career Choices Regarding Internal Medicine. JAMA 2008, 300: 1154-1164. PMID: 18780844, DOI: 10.1001/jama.300.10.1154.Peer-Reviewed Original ResearchConceptsStudents' career choicesCareer choiceEducational experienceCareer decision makingIM clerkshipMedical studentsFourth-year medical studentsMedical student career choiceGeneral internal medicineUS medical schoolsMedical student interestSubspecialty internal medicineInternal medicineStudent interestPrivate schoolsUS physician workforceMedical schoolsFavorable impressionStudentsCareerPhysician workforcePractice environmentClerkshipFavorable feelingsSchools
2005
Racial Disparities in Stroke Risk Factors
Bravata DM, Wells CK, Gulanski B, Kernan WN, Brass LM, Long J, Concato J. Racial Disparities in Stroke Risk Factors. Stroke 2005, 36: 1507-1511. PMID: 15961710, DOI: 10.1161/01.str.0000170991.63594.b6.Peer-Reviewed Original ResearchConceptsStroke risk factorsRisk factorsStroke historyHigh prevalenceLow high-density lipoprotein cholesterolHigher C-reactive proteinHigh-density lipoprotein cholesterolCommunity-dwelling stroke survivorsC-reactive proteinThird National HealthSevere strokeLipoprotein cholesterolMyocardial infarctionNational HealthStroke survivorsNutrition SurveyHigh incidenceUS populationStrokeOlder ageCross-sectional samplePrevalenceRacial disparitiesEthnic differencesAssociation
2003
Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable
Broderick JP, Viscoli CM, Brott T, Kernan WN, Brass LM, Feldmann E, Morgenstern LB, Wilterdink JL, Horwitz RI. Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable. Stroke 2003, 34: 1375-1381. PMID: 12764233, DOI: 10.1161/01.str.0000074572.91827.f4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionBody Mass IndexCase-Control StudiesCocaine-Related DisordersCohort StudiesComorbidityCooperative BehaviorFemaleHumansHypertensionLogistic ModelsMaleMiddle AgedOdds RatioPhenylpropanolamineRisk FactorsSex DistributionSmokingStrokeSubarachnoid HemorrhageThinnessUnited StatesConceptsAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageRisk factorsLower body mass indexIndependent risk factorCurrent cigarette smokersPrevalent risk factorsBody mass indexMajor risk factorCase-control studyYears of ageRandom digit dialingWarrants further studyHemorrhagic strokeIntracerebral hemorrhageCigarette smokersMass indexPreventable diseaseWomen 18Multivariable modelFamily historyCase subjectsAssociation of caffeineCocaine useHemorrhageUse of Ephedra-containing products and risk for hemorrhagic stroke
Morgenstern LB, Viscoli CM, Kernan WN, Brass LM, Broderick JP, Feldmann E, Wilterdink JL, Brott T, Horwitz RI. Use of Ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003, 60: 132-135. PMID: 12525737, DOI: 10.1212/01.wnl.0000042092.20411.5b.Peer-Reviewed Original Research