2001
Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis
Mehal W, Azzaroli F, Crispe I. Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis. The Journal Of Immunology 2001, 167: 667-673. PMID: 11441069, DOI: 10.4049/jimmunol.167.2.667.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationApoptosisBone Marrow CellsBone Marrow TransplantationCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity, ImmunologicLiverLymphocyte ActivationLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, TransgenicRadiation ChimeraSpleenStem Cell TransplantationStem CellsConceptsMarrow-derived cellsNon-bone marrow-derived cellsT cellsT cell apoptosisAg presentationLiver injuryBone marrow-derived cellsCell apoptosisSuch liver injuryT cell trappingT cell accumulationBone marrow chimerasTCR transgenic miceT cell populationsT cell deletionAdoptive transferIntrahepatic accumulationLiver damageHepatocyte damageSystemic activationAntigen presentationBone marrowCell accumulationClonal expansionCell deletion
2000
The liver as a site of T‐cell apoptosis: graveyard, or killing field?
Crispe I, Dao T, Klugewitz K, Mehal W, Metz D. The liver as a site of T‐cell apoptosis: graveyard, or killing field? Immunological Reviews 2000, 174: 47-62. PMID: 10807506, DOI: 10.1034/j.1600-0528.2002.017412.x.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntigensApoptosisCD8-Positive T-LymphocytesCell AdhesionEndothelium, VascularFas ReceptorHepatitis CHumansImmune ToleranceImmunophenotypingIntestinal AbsorptionKiller Cells, NaturalKupffer CellsLiverLiver CirculationLiver TransplantationLymphocyte ActivationLymphocyte SubsetsMiceMice, TransgenicModels, ImmunologicalPortal VeinConceptsT cellsNatural killerT cell trappingNK T cellsPeripheral immune responsePortal vein infusionApoptotic T cellsT cell apoptosisNormal mouse liverPhenomenon of toleranceApoptotic CD8Liver allograftsOral toleranceHepatitis C.Lymphocyte populationsAntigenic cellsImmune responseLiver pathogensVein infusionClearance phaseLiver resultsLiverDirect perfusionMouse liverCell populations
1998
TCR ligation on CD8+ T cells creates double-negative cells in vivo.
Mehal W, Crispe I. TCR ligation on CD8+ T cells creates double-negative cells in vivo. The Journal Of Immunology 1998, 161: 1686-93. PMID: 9712032, DOI: 10.4049/jimmunol.161.4.1686.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingCD8-Positive T-LymphocytesClonal DeletionFas ReceptorHistocompatibility Antigens Class IImmunophenotypingInjections, IntraperitonealLiverLymph NodesLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte Subsets