2019
A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Moher D, Hutton B. A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PLOS ONE 2019, 14: e0221713. PMID: 31498809, PMCID: PMC6733451, DOI: 10.1371/journal.pone.0221713.Peer-Reviewed Original ResearchConceptsIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossSensorineural hearing lossPTA improvementSystemic steroidsHearing recoveryHearing lossHigh riskManagement of ISSNHLSystematic reviewPure-tone average improvementSystemic steroid treatmentCause of disabilityExperienced information specialistSelection of treatmentQuality of lifeMajority of casesRemoval of duplicatesIntratympanic steroidsIntravenous steroidsIT steroidsOral steroidsPharmacologic therapySteroid treatmentActive treatment
2018
A protocol for a network meta-analysis of interventions to treat patients with sudden sensorineural hearing loss
Ahmadzai N, Kilty S, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Cheng W, Skidmore B, Moher D, Hutton B. A protocol for a network meta-analysis of interventions to treat patients with sudden sensorineural hearing loss. Systematic Reviews 2018, 7: 74. PMID: 29769117, PMCID: PMC5956787, DOI: 10.1186/s13643-018-0736-3.Peer-Reviewed Original ResearchMeSH KeywordsHearing Loss, SensorineuralHearing Loss, SuddenHumansNetwork Meta-AnalysisNoiseQuality of LifeTreatment OutcomeConceptsSudden sensorineural hearing lossIdiopathic sudden sensorineural hearing lossSensorineural hearing lossQuality of lifeHearing lossSystematic reviewExperienced medical information specialistPoor functional statusClinical Trials RegistryPre-specified eligibility criteriaIncidence of harmsCause of disabilityMeasurable hearing lossRisk of anxietyClinical treatment strategiesPlanned systematic reviewOptimal clinical treatment strategiesMajority of casesMedical information specialistBackgroundHearing lossCochrane riskHearing recoveryBias toolTrials RegistryTherapeutic options