The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis
Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH. The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis. Transfusion Medicine Reviews 2018, 32: 165-178. PMID: 29567052, DOI: 10.1016/j.tmrv.2018.02.003.Peer-Reviewed Original ResearchTopical tranexamic acidTranexamic acidBlood lossIntravenous administrationTransfusion requirementsTopical applicationIntravenous tranexamic acidNon-surgical trialsVenous thromboembolic complicationsMean blood lossCochrane Central RegisterFull-text selectionMajority of trialsEffective hemostatic agentIntravenous groupThromboembolic riskVenous thromboembolismAdult patientsCentral RegisterThromboembolic complicationsBlood transfusionControlled TrialsTransfusion riskSafety profileSystemic absorption