Featured Publications
Necrotizing Soft Tissue Infection
Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection. Annals Of Surgery 2019, 269: 58-65. PMID: 29672405, DOI: 10.1097/sla.0000000000002774.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsTissue infectionsComputed tomographyPlain radiographyEarly surgical consultationPhysical examination signsLife-threatening diagnosisLaboratory Risk IndicatorNecrotizing Fasciitis (LRINEC) scorePhysical examination featuresPoor sensitivityEnglish-language studiesHierarchical summary receiverExamination signsFasciitis (LRINEC) scoreLRINEC scoreSurgical managementPhysical examinationSurgical consultationDefinitive diagnosisExamination featuresBACKGROUND DATANSTI
2023
Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis
Wilson S, Thavanathan R, Cheng W, Stuart J, Kim D, Glen P, Duigenan S, Shorr R, Woo M, Perry J. Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis. Annals Of Emergency Medicine 2023, 83: 235-246. PMID: 37855790, DOI: 10.1016/j.annemergmed.2023.09.005.Peer-Reviewed Original ResearchEmergency physician-performed pointAcute cholecystitisCare ultrasoundSystematic reviewFinal diagnosisDiagnostic accuracyEarly surgical managementAcute abdominal painMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsFull-text reviewTitles/abstractsReference standardPositive likelihood ratioHierarchical summary receiverNegative likelihood ratioAbdominal painLikelihood ratioClinical suspicionHospital admissionDefinitive managementSurgical managementEmergency departmentBias assessmentEligible studies
2019
Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. The BMJ 2019, 366: l4225. PMID: 31340932, PMCID: PMC6651068, DOI: 10.1136/bmj.l4225.Peer-Reviewed Original ResearchConceptsElevated intracranial pressureOptic nerve sheath diameterIntracranial pressureNon-invasive testsMidline shiftIll patientsPhysical examinationSystematic reviewPhysical examination signsDoppler pulsatility indexGlasgow Coma ScaleNerve sheath diameterInvasive ICP monitoringPhysical examination featuresPatient-level dataDiagnostic Accuracy Studies toolTranscranial Doppler pulsatility indexEnglish-language studiesHierarchical summary receiverExamination signsComa ScaleCT findingsIll adultsPulsatility indexBasal cisternsDiagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.
Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE. Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review. Journal Of Bone And Joint Surgery 2019, 101: 635-649. PMID: 30946198, DOI: 10.2106/jbjs.18.00632.Peer-Reviewed Original ResearchConceptsChronic periprosthetic joint infectionPeriprosthetic joint infectionHigh riskTissue-based testsJoint infectionKnee replacementSystematic reviewC-reactive protein levelsWhite blood cell countDiagnostic accuracyDiagnostic testsDiagnostic Accuracy Studies-2 toolShort-term mortalityBlood cell countPolymorphonuclear neutrophil percentageAlpha-defensin testLeukocyte esterase reagent stripsTotal joint replacementHierarchical summary receiverDiagnostic test resultsDevastating complicationPeer-reviewed journalsNeutrophil percentagePoor outcomeCochrane Library