Featured Publications
Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine 2020, 46: 1170-1179. PMID: 32306086, PMCID: PMC7223448, DOI: 10.1007/s00134-020-06036-z.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaEndotracheal aspiratesChest radiographyDiagnosis of VAPBronchoscopic sampling methodsIll adult patientsPhysical examination findingsEnglish-language studiesUnnecessary antimicrobial useAdult patientsVAP diagnosisPurulent secretionsExamination findingsPhysical examinationClinical indicatorsAntibiotic treatmentHistopathological analysisStudy qualitySystematic reviewAntimicrobial usePooled sensitivityDiagnosisPneumoniaReference standardRadiographyPre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. The BMJ 2019, 367: l6373. PMID: 31801749, PMCID: PMC6891802, DOI: 10.1136/bmj.l6373.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestPrognostic factorsSystematic reviewReduced oddsPrimary analysisInitial shockable rhythmIntra-arrest factorsPre-arrest factorsHigh-certainty evidenceChronic kidney diseaseDuration of resuscitationRisk of biasEnglish-language studiesWeb of ScienceActive malignancyCertainty evidenceCohort studyGRADE approachOdds of survivalCochrane DatabaseMale sexKidney diseaseShockable rhythmRelevant confoundersNecrotizing Soft Tissue Infection
Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection. Annals Of Surgery 2019, 269: 58-65. PMID: 29672405, DOI: 10.1097/sla.0000000000002774.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsTissue infectionsComputed tomographyPlain radiographyEarly surgical consultationPhysical examination signsLife-threatening diagnosisLaboratory Risk IndicatorNecrotizing Fasciitis (LRINEC) scorePhysical examination featuresPoor sensitivityEnglish-language studiesHierarchical summary receiverExamination signsFasciitis (LRINEC) scoreLRINEC scoreSurgical managementPhysical examinationSurgical consultationDefinitive diagnosisExamination featuresBACKGROUND DATANSTI
2019
Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. The BMJ 2019, 366: l4225. PMID: 31340932, PMCID: PMC6651068, DOI: 10.1136/bmj.l4225.Peer-Reviewed Original ResearchConceptsElevated intracranial pressureOptic nerve sheath diameterIntracranial pressureNon-invasive testsMidline shiftIll patientsPhysical examinationSystematic reviewPhysical examination signsDoppler pulsatility indexGlasgow Coma ScaleNerve sheath diameterInvasive ICP monitoringPhysical examination featuresPatient-level dataDiagnostic Accuracy Studies toolTranscranial Doppler pulsatility indexEnglish-language studiesHierarchical summary receiverExamination signsComa ScaleCT findingsIll adultsPulsatility indexBasal cisterns
2018
Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis.
Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, Perry JJ. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis. Annals Of Internal Medicine 2018, 168: 266-275. PMID: 29404582, DOI: 10.7326/m17-2820.Peer-Reviewed Original ResearchConceptsQuick Sequential Organ Failure AssessmentPrediction of mortalitySequential Organ Failure AssessmentOrgan Failure AssessmentIntensive care unitNon-ICU populationSIRS criteriaICU populationAdult patientsPooled specificityEmergency departmentPooled sensitivityPrognostic accuracySystemic inflammatory response syndrome criteriaShort-term mortalityScreening of patientsFailure AssessmentEnglish-language studiesSyndrome criteriaTreatment initiationCare unitPatient selectionStudy qualityEmergency physiciansHospital wards