Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.
Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE. Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review. Journal Of Bone And Joint Surgery 2019, 101: 635-649. PMID: 30946198, DOI: 10.2106/jbjs.18.00632.Peer-Reviewed Original ResearchConceptsChronic periprosthetic joint infectionPeriprosthetic joint infectionHigh riskTissue-based testsJoint infectionKnee replacementSystematic reviewC-reactive protein levelsWhite blood cell countDiagnostic accuracyDiagnostic testsDiagnostic Accuracy Studies-2 toolShort-term mortalityBlood cell countPolymorphonuclear neutrophil percentageAlpha-defensin testLeukocyte esterase reagent stripsTotal joint replacementHierarchical summary receiverDiagnostic test resultsDevastating complicationPeer-reviewed journalsNeutrophil percentagePoor outcomeCochrane Library