Featured Publications
Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study
Calder LA, Perry J, Yan JW, De Gorter R, Sivilotti MLA, Eagles D, Myslik F, Borgundvaag B, Émond M, McRae AD, Taljaard M, Thiruganasambandamoorthy V, Cheng W, Forster AJ, Stiell IG. Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study. Annals Of Emergency Medicine 2021, 77: 561-574. PMID: 33612283, DOI: 10.1016/j.annemergmed.2020.12.012.Peer-Reviewed Original ResearchConceptsAcute heart failureAdverse eventsEmergency department patientsED visitsDepartment patientsHeart failureAtrial fibrillationHealth care provider visitsRecent-onset atrial fibrillationClinical practice guideline adherenceIndex ED visitPractice guideline adherenceAdverse event incidenceProspective cohort studyAdverse event ratesCase summariesQuality improvement opportunitiesFactor themesAdverse event typesCanadian EDsSentinel diagnosesED dischargeProvider visitsAdult patientsCohort studyOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials RegistryDiagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine 2020, 46: 1170-1179. PMID: 32306086, PMCID: PMC7223448, DOI: 10.1007/s00134-020-06036-z.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaEndotracheal aspiratesChest radiographyDiagnosis of VAPBronchoscopic sampling methodsIll adult patientsPhysical examination findingsEnglish-language studiesUnnecessary antimicrobial useAdult patientsVAP diagnosisPurulent secretionsExamination findingsPhysical examinationClinical indicatorsAntibiotic treatmentHistopathological analysisStudy qualitySystematic reviewAntimicrobial usePooled sensitivityDiagnosisPneumoniaReference standardRadiographyAccuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis
Zheng B, Toarta C, Cheng W, Taljaard M, Reaume N, Perry JJ. Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis. Critical Reviews In Oncology/Hematology 2020, 149: 102922. PMID: 32244162, DOI: 10.1016/j.critrevonc.2020.102922.Peer-Reviewed Original ResearchConceptsMultinational AssociationSupportive careSerious complicationsClinical indicesPooled sensitivitySystematic reviewFebrile neutropenia patientsCISNE scoreMASCC scoreFebrile neutropeniaAcute settingAdult patientsCochrane DatabaseNeutropenia patientsPatientsComplicationsScoresCancerCareAssociationSpecificityNeutropeniaMASCCEMBASEReviewPrognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ. Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis. Academic Emergency Medicine 2018, 26: 140-151. PMID: 30375097, DOI: 10.1111/acem.13649.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsPrediction of MACEAdverse cardiac eventsHEART scorePrediction of mortalityChest painMyocardial infarctionPrognostic accuracyCardiac eventsTIMI scoreLow-risk thresholdSystematic reviewPrediction of MIMyocardial Infarction (TIMI) scoreAdult ED patientsChest pain patientsShort-term incidenceClinical decision instrumentWeb of ScienceAdult patientsPain patientsED patientsRisk stratificationCochrane DatabasePatient population
2023
Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, DOI: 10.1159/000530153.Peer-Reviewed Original ResearchConceptsAML/myelodysplastic syndromeAcute myeloid leukemiaInternational normalized ratioAntibacterial prophylaxisMyelodysplastic syndromeProphylactic antibacterialsCoagulation profileAcute myeloid leukemia/myelodysplastic syndromeDiagnosis of AMLHigher international normalized ratioLeukemia/myelodysplastic syndromePartial thromboplastin time prolongationYale-New Haven HospitalYale-New HavenRetrospective cohort studyAbnormal coagulation profileGroup of patientsTime of admissionHigh rateIndividual patient encountersInstitutional review boardAntibacterial exposureRelevant bleedingAdult patientsCohort study
2020
Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis
Deng J, Silver Z, Huang E, Zheng E, Kavanagh K, Wen A, Cheng W, Dobransky J, Sanger S, Grammatopoulos G. Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis. Rheumatology 2020, 60: 649-657. PMID: 32572480, DOI: 10.1093/rheumatology/keaa228.Peer-Reviewed Original ResearchConceptsNon-vertebral fracturesDecreased oddsAdult patientsSystematic reviewNon-vertebral fracture incidenceAnti-fracture efficacyCochrane Central RegisterSystematic review registrationVitamin D metabolitesAllied Health LiteratureInternational Prospective RegisterWeb of ScienceGlucocorticoid therapyEligible patientsCentral RegisterControlled TrialsPharmacological preventionVertebral fracturesFracture incidenceReview registrationGC therapyVitamin D.D metabolitesProspective RegisterI2 statistic
2018
The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis
Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH. The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis. Transfusion Medicine Reviews 2018, 32: 165-178. PMID: 29567052, DOI: 10.1016/j.tmrv.2018.02.003.Peer-Reviewed Original ResearchTopical tranexamic acidTranexamic acidBlood lossIntravenous administrationTransfusion requirementsTopical applicationIntravenous tranexamic acidNon-surgical trialsVenous thromboembolic complicationsMean blood lossCochrane Central RegisterFull-text selectionMajority of trialsEffective hemostatic agentIntravenous groupThromboembolic riskVenous thromboembolismAdult patientsCentral RegisterThromboembolic complicationsBlood transfusionControlled TrialsTransfusion riskSafety profileSystemic absorptionPrognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis.
Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, Perry JJ. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis. Annals Of Internal Medicine 2018, 168: 266-275. PMID: 29404582, DOI: 10.7326/m17-2820.Peer-Reviewed Original ResearchConceptsQuick Sequential Organ Failure AssessmentPrediction of mortalitySequential Organ Failure AssessmentOrgan Failure AssessmentIntensive care unitNon-ICU populationSIRS criteriaICU populationAdult patientsPooled specificityEmergency departmentPooled sensitivityPrognostic accuracySystemic inflammatory response syndrome criteriaShort-term mortalityScreening of patientsFailure AssessmentEnglish-language studiesSyndrome criteriaTreatment initiationCare unitPatient selectionStudy qualityEmergency physiciansHospital wards