2023
IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING
Dixit V. IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING. Innovation In Aging 2023, 7: 140-140. PMCID: PMC10735998, DOI: 10.1093/geroni/igad104.0458.Peer-Reviewed Original ResearchCaloric restrictionAnti-inflammatory effectsAnti-inflammatory responseAge-related functional declineNegative energy balanceTissue-resident macrophagesAge-associated degenerative diseasesThymic involutionMaintenance of homeostasisMetabolic dysfunctionFunctional declineAdipose tissueInflammationResident macrophagesStudy participantsDegenerative diseasesMacrophagesKey hallmarksRNA sequence analysisMitochondrial metabolismHuman physiologyUnique regulatorCellular quiescenceMetabolismTranscriptional programsWhen a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
Mihaylova M, Chaix A, Delibegovic M, Ramsey J, Bass J, Melkani G, Singh R, Chen Z, Ja W, Shirasu-Hiza M, Latimer M, Mattison J, Thalacker-Mercer A, Dixit V, Panda S, Lamming D. When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging. Cell Metabolism 2023, 35: 1114-1131. PMID: 37392742, PMCID: PMC10528391, DOI: 10.1016/j.cmet.2023.06.008.Peer-Reviewed Original ResearchConceptsCalorie restrictionHealthy agingEpidemic of obesityTime-restricted feedingWhole-body metabolismMacronutrient sourcesAge-associated diseasesCardiovascular diseaseNovel therapiesMetabolic effectsMacronutrient compositionDiet qualityMedicine approachNIH workshopCaloriesMetabolic responseDiseaseMediators of metabolismDietary compositionMolecular mechanismsRecent findingsMetabolismObesityDiabetesTherapy
2020
Dietary Regulation of Immunity
Lee AH, Dixit VD. Dietary Regulation of Immunity. Immunity 2020, 53: 510-523. PMID: 32937152, PMCID: PMC7491384, DOI: 10.1016/j.immuni.2020.08.013.Peer-Reviewed Original ResearchConceptsDietary intakeOrganismal metabolismRestoration of homeostasisRegulation of glucoseMacronutrient intakeImmune regulationImmunological functionsImmunological responseImmunometabolic responsesMitochondrial respirationImmune systemInsulin actionDietary regulationProtein metabolismTissue functionIntakeDietary surplusRegulationVital functionsImmunityMetabolismHealthspanLeukocytesCheckpointHomeostasis