2022
Immune cells use hunger hormones to aid healing
Dixit VD. Immune cells use hunger hormones to aid healing. Nature 2022, 609: 39-40. PMID: 35948678, DOI: 10.1038/d41586-022-02105-z.Peer-Reviewed Original Research
2020
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nature Metabolism 2020, 2: 50-61. PMID: 32694683, PMCID: PMC10150608, DOI: 10.1038/s42255-019-0160-6.Peer-Reviewed Original ResearchConceptsΓδ T cellsKetogenic dietT cellsAdipose tissue inflammationResident immune cellsVisceral adipose tissueHigher fat compositionReduced adipose tissue inflammationCause obesityMetabolic healthTissue inflammationImmune cellsImmunometabolic responsesProlonged exerciseGlucose homeostasisAdipose tissueInflammationKetone bodiesSingle-cell RNA sequencingLow carbohydrateEnergy homeostasisΒ-hydroxybutyrateFat compositionRNA sequencingCells
2019
AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS
Camell C, Dixit V. AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS. Innovation In Aging 2019, 3: s106-s106. PMCID: PMC6845598, DOI: 10.1093/geroni/igz038.397.Peer-Reviewed Original ResearchFat-associated lymphoid clustersTissue B cellsB cell expansionAdipose tissueB cellsNLRP3 inflammasomeAdipose tissue immune cellsVisceral white adipose tissueB cell profileB-cell depletionB cell accumulationTissue immune cellsVisceral adipose tissueWhite adipose tissueAged B cellsFALC formationVisceral adiposityCell depletionInduces NLRP3Aged miceImmune cellsInsulin sensitivityFemale miceLymphoid clustersMetabolic dysfunction
2017
Energy Sparing Orexigenic Inflammation of Obesity
Lee A, Dixit VD. Energy Sparing Orexigenic Inflammation of Obesity. Cell Metabolism 2017, 26: 10-12. PMID: 28683278, DOI: 10.1016/j.cmet.2017.06.013.Peer-Reviewed Original ResearchNLRP3 Inflammasome controls adipose tissue macrophage activation during aging
Camell C, Sander J, Spadaro O, Lee A, Nguyen K, Wing A, Goldberg E, Youm Y, Rodeheffer M, Schultze J, Dixit V. NLRP3 Inflammasome controls adipose tissue macrophage activation during aging. The Journal Of Immunology 2017, 198: 154.3-154.3. DOI: 10.4049/jimmunol.198.supp.154.3.Peer-Reviewed Original ResearchAge-related inflammationMacrophage activationAT macrophagesImmune-metabolic interactionsCaspase-1 activationAdipose tissue homeostasisAge-related defectsAT inflammationOld WTVisceral adiposityImmune defectsChronic inflammationInsulin resistanceAged miceImmune populationsImmune cellsInflammatory responseMetabolic dysfunctionAge-induced changesMacrophage subsetsMultiple organsInflammationNLRP3Tissue macrophagesDegenerative disorders
2015
NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331)
Camell C, Youm Y, Nguyen K, Ravussin A, Spadaro O, Dixit V. NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331). The Journal Of Immunology 2015, 194: 193.5-193.5. DOI: 10.4049/jimmunol.194.supp.193.5.Peer-Reviewed Original ResearchAge-related inflammationAdipose tissueAged miceAntigen-specific T cellsDistinct inflammatory signatureB cell infiltrationSpecific T cellsOld control miceVisceral adipose tissueIL-1β signalingB cell subpopulationsAT inflammationAT macrophagesInflammatory signatureVisceral adiposityImmune defectsChronic inflammationControl miceInsulin resistanceLymphocyte clustersCell infiltrationImmune cellsMetabolic dysfunctionT cellsAge-induced changesAdipose tissue as an immunological organ
Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity 2015, 23: 512-518. PMID: 25612251, PMCID: PMC4340740, DOI: 10.1002/oby.21003.Peer-Reviewed Original ResearchConceptsAdipose tissueImmunological organActive immunological organNumerous immune cellsObesity-associated comorbiditiesImmune cell subtypesAdaptive immune responsesType 2 diabetesCertain infectious diseasesWhole-body metabolismMetabolic syndromeObese subjectsChronic inflammationImmunological aspectsInsulin resistanceTissue inflammationObesity influencesImmune cellsImmune surveillanceT cellsImmune responseTissue leukocytosisPubMed searchB cellsHost defense