2022
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity 2022, 55: 1609-1626.e7. PMID: 35963236, PMCID: PMC9474643, DOI: 10.1016/j.immuni.2022.07.007.Peer-Reviewed Original ResearchConceptsToll-like receptor 4ISG inductionMatricellular proteinPro-inflammatory phenotypeAnti-inflammatory macrophagesInterferon-stimulated gene expressionAdipocyte-specific deletionInhibition of glycolysisImmunometabolic adaptationsMyD88 pathwayReceptor 4Chronic diseasesFunctional declineCaloric restrictionInterferon responseHealth spanMacrophagesInflammationMitochondrial respirationSPARCInductionGene expressionAdipokinesObesityIFN
2015
Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)
Goldberg E, Youm Y, Nguyen K, Alnemri E, Dixit V. Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153). The Journal Of Immunology 2015, 194: 48.10-48.10. DOI: 10.4049/jimmunol.194.supp.48.10.Peer-Reviewed Original ResearchBeta-hydroxy butyrateInflammasome activationMyeloid cellsNLRP3-dependent inflammasome activationAnti-inflammatory interventionsNLRP3-dependent ILMyeloid lineage cellsShort-chain fatty acidsDependent inflammasome activationKetone body productionFatty acid oxidationBone lossChronic inflammationAge-related diseasesAged miceNLRP3 inflammasomeSterile inflammationChronic diseasesFunctional declineMetabolic diseasesCognitive declineCalorie restrictionChain fatty acidsInflammationLineage cells