2021
Face Perception Predicts Affective Theory of Mind in Autism Spectrum Disorder but Not Schizophrenia or Typical Development
Altschuler MR, Trevisan DA, Wolf JM, Naples AJ, Foss-Feig JH, Srihari VH, McPartland JC. Face Perception Predicts Affective Theory of Mind in Autism Spectrum Disorder but Not Schizophrenia or Typical Development. Journal Of Psychopathology And Clinical Science 2021, 130: 413-422. PMID: 34180705, PMCID: PMC8244155, DOI: 10.1037/abn0000621.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBenton Facial Recognition TestSchizophrenia spectrum disordersAffective ToM abilitiesTypical developmentSpectrum disorderAffective ToMToM difficultiesSocial cognitionToM abilitiesIndividual differencesBetter face recognition abilityFace recognition abilityFace recognition difficultiesTheory of mindFacial Recognition TestFull Scale IQFace perceptionAffective theoryRecognition difficultiesRecognition testEyes TestSocial dysfunctionRecognition abilityFace recognition
2020
Analysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original ResearchCognitive Effort and Amotivation in First-Episode Psychosis
Fortgang RG, Srihari V, Cannon TD. Cognitive Effort and Amotivation in First-Episode Psychosis. Journal Of Psychopathology And Clinical Science 2020, 129: 422-431. PMID: 32162929, DOI: 10.1037/abn0000509.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionFemaleHumansMaleMotivationNeuropsychological TestsPsychotic DisordersYoung AdultConceptsCognitive effortFirst-episode psychosisCognitive test performanceObserved cognitive deficitsAdditional monetary incentivesCognitive remediationCognitive tasksCognitive performanceDifficult trialsNovel taskCognitive deficitsAmotivationImpaired cognitionTest performanceCore featuresDisengagementLower overall accuracyHealthy community membersMonetary incentivesCurrent studyEpisode psychosisFEP patientsPsychotic disordersReduced effortTask
2019
Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study
Ferrara M, Guloksuz S, Li F, Burke S, Tek C, Friis S, Ten Velden Hegelstad W, Joa I, Johannessen JO, Melle I, Simonsen E, Srihari VH. Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study. Schizophrenia Research 2019, 210: 128-134. PMID: 31204063, DOI: 10.1016/j.schres.2019.05.035.Peer-Reviewed Original ResearchEarly intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services
2018
Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300
Hamilton HK, Woods SW, Roach BJ, Llerena K, McGlashan TH, Srihari VH, Ford JM, Mathalon DH. Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300. Schizophrenia Bulletin 2018, 45: 1068-1080. PMID: 30753731, PMCID: PMC6737543, DOI: 10.1093/schbul/sby167.Peer-Reviewed Original ResearchConceptsPsychosis risk syndromeTarget P3bProcessing deficitsPsychosis onsetEvent-related potential componentP300 event-related potential componentTarget P3b amplitudesPsychosis riskInfrequent target stimuliVisual oddball taskPRS participantsHealthy control participantsP3b amplitudeVisual modalityTarget stimuliP3a amplitudeSchizophrenia participantsOddball taskNovel stimuliP300 amplitudeHC participantsRisk syndromeP3bVulnerability markerControl participantsCourse, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
Kang C, Zhou H, Yang J, Yang R, Sun N, Wang S, Yang C, Han D, Srihari VH. Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. Psychiatry Research 2018, 271: 144-149. PMID: 30472510, DOI: 10.1016/j.psychres.2018.11.013.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaICD-10 diagnosisDiagnostic stabilityMini International Neuropsychiatric InterviewFirst Affiliated HospitalInternational Neuropsychiatric InterviewKunming Medical UniversityHigh diagnostic stabilityDepartment of PsychiatryPoor outcomeAffiliated HospitalNeuropsychiatric InterviewInternational ClassificationBetter outcomesModerate outcomeMedical UniversityGlobal functioningICD-10Psychosocial outcomesPatientsSchizophreniaDiagnosis stabilityDiagnosisOutcomesHospitalDevelopment and validation of the client engagement and service use scale: A pilot study
Kline ER, DeTore NR, Keefe K, Seidman LJ, Srihari VH, Keshavan MS, Guyer M. Development and validation of the client engagement and service use scale: A pilot study. Schizophrenia Research 2018, 201: 343-346. PMID: 29764759, DOI: 10.1016/j.schres.2018.05.006.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisEpisode psychosisService utilizationPilot studyService Engagement ScaleMultiple intervention componentsClients' service utilizationClient engagementMedication adherenceSpecialty careEarly treatmentInter-rater reliabilitySession attendanceHigh inter-rater reliabilityTreatment teamIntervention componentsSpecialized treatmentMenu of servicesPreliminary evidenceCliniciansPsychosisConsumer advocacy groupsUse ScaleTreatmentMinimal trainingEffects of Reward on Spatial Working Memory in Schizophrenia
Cho YT, Lam NH, Starc M, Santamauro N, Savic A, Diehl CK, Schleifer CH, Moujaes F, Srihari VH, Repovs G, Murray JD, Anticevic A. Effects of Reward on Spatial Working Memory in Schizophrenia. Journal Of Psychopathology And Clinical Science 2018, 127: 695-709. PMID: 30335439, PMCID: PMC6197071, DOI: 10.1037/abn0000369.Peer-Reviewed Original ResearchAn Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector.
Murphy SM, Kucukgoncu S, Bao Y, Li F, Tek C, Breitborde NJK, Guloksuz S, Phutane VH, Ozkan B, Pollard JM, Cahill JD, Woods SW, Cole RA, Schoenbaum M, Srihari VH. An Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector. The Journal Of Mental Health Policy And Economics 2018, 21: 123-130. PMID: 30530872, PMCID: PMC6314808.Peer-Reviewed Original ResearchConceptsSpecialty care servicesPatient costsEarly intervention servicesUsual treatmentSchizophrenia spectrum disordersMonth 12Economic evaluationCare servicesSTEP participantsCommunity mental health centerThird-party payer perspectiveIntervention servicesFirst-episode servicesMonths post randomizationHealthcare service utilizationMental health centersU.S. public sectorTeam-based careCost-offset analysisEligible patientsThird-party payersAntipsychotic exposureED visitsMonth 6Episode psychosisBlind Spots: Spatial analytics can identify nonrandom geographic variation in first episode psychosis program enrollments
Mathis WS, Woods S, Srihari V. Blind Spots: Spatial analytics can identify nonrandom geographic variation in first episode psychosis program enrollments. Early Intervention In Psychiatry 2018, 12: 1229-1234. PMID: 29927083, DOI: 10.1111/eip.12681.Peer-Reviewed Original ResearchConceptsPrimary care providersCare providersControl populationFirst episode psychosis programProgram enrollmentProgram catchment areaProvider Enumeration SystemPsychosis programSpecialty clinicRecruitment interventionsRisk populationsProgram enrolleesPositive findingsUS Census dataStatistical significanceHome addressEnrollmentEnrolleesProgram participantsPreliminary studyPopulationEnumeration systemFindingsProvidersClinicShould I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis
Fryer SL, Roach BJ, Ford JM, Donaldson KR, Calhoun VD, Pearlson GD, Kiehl KA, Srihari VH, McGlashan TH, Woods SW, Mathalon DH. Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis. Schizophrenia Bulletin 2018, 45: 158-168. PMID: 29385625, PMCID: PMC6293268, DOI: 10.1093/schbul/sbx198.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high riskESZ groupsBilateral dorsal anterior cingulateResponse inhibitionGo/NoGo task performanceEarly illness schizophreniaInhibitory control regionsVariable motor responseTask-based functional connectivityFunctional connectivity relationshipsDorsal anterior cingulateMedial prefrontal cortexDefault mode network regionsInferior frontal cortexRight inferior frontal regionsFunctional magnetic resonanceFrontal cortexHigh riskHealthy adolescentsSchizophrenia patientsAnterior cingulateControl groupInferior frontal regionsCHR group
2015
First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial
Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric Services 2015, 66: 705-712. PMID: 25639994, PMCID: PMC4490067, DOI: 10.1176/appi.ps.201400236.Peer-Reviewed Original ResearchConceptsUsual treatmentSTEP participantsCommunity mental health centerFirst-episode servicesFirst-episode psychosisMental health centersSerious mental illnessInpatient psychiatric unitAntipsychotic exposureAdditional patientsIllness onsetHospital utilizationHealth centersInpatient utilizationPsychiatric hospitalizationMAIN OUTCOMEPsychotic illnessPsychiatric unitPsychotic disordersHospitalizationEarly interventionMental illnessSpecialized treatmentPatientsTranslational researchEquivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Hay RA, Roach BJ, Srihari VH, Woods SW, Ford JM, Mathalon DH. Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients. Biological Psychology 2015, 105: 130-137. PMID: 25603283, PMCID: PMC4336819, DOI: 10.1016/j.biopsycho.2015.01.004.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum patientsHealthy controlsEarly schizophrenia patientsMMN amplitude reductionDuration of illnessCourse of schizophreniaMismatch negativityDeviant typesMismatch negativity deficitsClinical symptomsDifferent deviant typesNeurophysiological abnormalitiesAuditory deviantsSchizophrenia patientsPatientsAuditory deviance processingIllnessNeurophysiological mechanismsAmplitude reductionSignificant interactionMMN responsesDeviance processingSymptomsAbnormalitiesSchizophrenia
2013
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biological Psychiatry 2013, 75: 459-469. PMID: 24050720, PMCID: PMC4028131, DOI: 10.1016/j.biopsych.2013.07.038.Peer-Reviewed Original ResearchConceptsCHR patientsHealthy control subjectsPsychosis onsetControl subjectsClinical high-risk patientsEarly illness schizophrenia patientsPsychosis riskClinical high-risk individualsHigh-risk patientsThird of patientsHigh-risk individualsCurrent clinical criteriaAuditory processing deficitsMismatch negativityNonclinical measuresAuditory devianceCox regressionClinical criteriaUnnecessary treatmentHigh riskCHR convertersPatientsPsychotic disordersSchizophrenia patientsPreventive interventionsCardiovascular mortality in schizophrenia: Defining a critical period for prevention
Srihari VH, Phutane VH, Ozkan B, Chwastiak L, Ratliff JC, Woods SW, Tek C. Cardiovascular mortality in schizophrenia: Defining a critical period for prevention. Schizophrenia Research 2013, 146: 64-68. PMID: 23422728, PMCID: PMC3622848, DOI: 10.1016/j.schres.2013.01.014.Peer-Reviewed Original ResearchConceptsPremature cardiovascular mortalityCardiovascular mortalityCardiovascular riskUrban community mental health centerCommunity mental health centerCardiovascular risk estimatesPrior antipsychotic exposureRace-matched peersCardiovascular risk factorsEarly psychosis clinicMental health centersSuch preventive effortsLow-risk categoryCritical periodAntipsychotic exposureBlood pressureMetabolic syndromeObese categoryPsychosis clinicNormal weightPrimary preventionRisk factorsNational HealthHealth centersNutrition SurveyChapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies
2012
Error Monitoring Dysfunction Across the Illness Course of Schizophrenia
Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error Monitoring Dysfunction Across the Illness Course of Schizophrenia. Journal Of Psychopathology And Clinical Science 2012, 121: 372-387. PMID: 22060947, PMCID: PMC3358508, DOI: 10.1037/a0025487.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high-risk patientsSchizophrenia patientsIllness courseAge-matched healthy controlsHigh-risk patientsAge-matched HCChronic schizophrenia patientsOnset of psychosisCorrect response negativityPE abnormalitiesRisk patientsCHR patientsClinical prodromeEvent-related potentialsIllness durationHealthy controlsIllness progressionPsychosis onsetPatientsAbnormalitiesIllnessResponse monitoringError-related negativityOnset
2011
Who Is Paying the Price? Loss of Health Insurance Coverage Early in Psychosis
Dodds TJ, Phutane VH, Stevens BJ, Woods SW, Sernyak MJ, Srihari VH. Who Is Paying the Price? Loss of Health Insurance Coverage Early in Psychosis. Psychiatric Services 2011, 62: 878-881. PMID: 21807825, PMCID: PMC4469900, DOI: 10.1176/ps.62.8.pss6208_0878.Peer-Reviewed Original ResearchConceptsHealth insurance coverageInsurance coverageConnecticut Mental Health CenterClinical chart reviewEarly psychosis patientsLong-term outcomesContinuity of careMental health centersPeriod of illnessChart reviewInsurance statusHealth centersEarly psychosisSpecialty servicesClinician reportsPrivate insurancePublic insuranceSpecialized treatmentPsychosisHealth insuranceMonthsOne-thirdParticipantsInsurancePatientsCardiovascular risk in a first-episode psychosis sample: A ‘critical period’ for prevention?
Phutane VH, Tek C, Chwastiak L, Ratliff JC, Ozyuksel B, Woods SW, Srihari VH. Cardiovascular risk in a first-episode psychosis sample: A ‘critical period’ for prevention? Schizophrenia Research 2011, 127: 257-261. PMID: 21242060, PMCID: PMC3051021, DOI: 10.1016/j.schres.2010.12.008.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseFirst-episode psychosis patientsFirst-episode psychosis sampleEpisode psychosis patientsHeart diseaseCardiovascular riskPsychosis patientsPlasma glucoseRisk factorsFirst-episode psychosis clinicNational Cholesterol Education ProgramPsychosis sampleCardiovascular risk factorsHigh cardiovascular riskStatus of diabetesCholesterol Education ProgramBody mass indexCommon medical illnessesU.S. National HealthNutrition Examination SurveyRace-matched controlsIndividual risk factorsEarly intervention clinicCross-sectional analysisCardiovascular morbidity