Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia
Goetzl EJ, Srihari VH, Mustapic M, Kapogiannis D, Heninger GR. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia. The FASEB Journal 2022, 36: e22466. PMID: 35867070, PMCID: PMC9358927, DOI: 10.1096/fj.202200792rr.Peer-Reviewed Original ResearchMeSH KeywordsCalciumDepressive Disorder, MajorExtracellular VesiclesGenome-Wide Association StudyHumansMembrane ProteinsMitochondrial ProteinsNeuronsSchizophreniaSodium-Calcium ExchangerConceptsNeuron-derived extracellular vesiclesChannel proteinsExtracellular vesiclesGenome-wide association studiesMitochondrial ion channelsIon channel proteinsIndividual proteinsLeucine zipperAssociation studiesMitochondrial NaMitochondrial levelTransient receptor potential cation channelMitochondrial Ca2Ion channelsSequence studiesProteinMember B1Extracted proteinsCation channelsNeuronal functionΑ-1CMember 4Calcium homeostasisVesiclesStructural alterations