2024
The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchMeSH KeywordsEarly DiagnosisHospitalizationHumansPsychotic DisordersSchizophrenic PsychologyTime FactorsConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effects
2023
The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service
Ferrara M, Guloksuz S, Hazan H, Li F, Tek C, Sykes L, Riley S, Keshavan M, Srihari V. The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service. Schizophrenia Research 2023, 260: 198-204. PMID: 37688984, DOI: 10.1016/j.schres.2023.08.005.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesLength of stayUntreated psychosisPsychiatric hospitalizationFirst-episode servicesDuration of hospitalizationIncidence rate ratiosNon-affective psychosisNew Haven areaPoisson regression modelsPatient characteristicsHospitalization ratesRecent onsetMedical recordsHospitalizationEffect of durationNegative binomial regressionSpecialized treatmentPsychosisRate ratioBinomial regressionAdmissionDUPEnrollmentFirst year
2022
DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.)
Srihari V, Li F. DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.). Schizophrenia Research 2022, 251: 46-48. PMID: 36565532, DOI: 10.1016/j.schres.2022.12.006.Peer-Reviewed Original Research
2021
First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care
Ferrara M, Guloksuz S, Mathis WS, Li F, Lin IH, Syed S, Gallagher K, Shah J, Kline E, Tek C, Keshavan M, Srihari VH. First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care. Social Psychiatry And Psychiatric Epidemiology 2021, 56: 1359-1369. PMID: 33948678, PMCID: PMC8319102, DOI: 10.1007/s00127-021-02090-0.Peer-Reviewed Original ResearchConceptsPsychosis onsetNon-affective psychosisPsychosis risk syndromeEarly detection effortsAversive eventsAversive pathwaysProdromal sampleClinical characteristicsAntipsychotic treatmentEffective treatmentSociodemographic characteristicsSpecialized treatmentPsychosisProdromeOnsetTreatmentStructured interviewsOverall functioningFamily membersMeasures of delayEpisodesNew HavenSemi-structured interviewsHelp seekersPathway
2016
Analyzing the Duration of Untreated Psychosis: Quantile Regression
Guloksuz S, Li F, Tek C, Woods SW, McGlashan TH, Friis S, Srihari VH. Analyzing the Duration of Untreated Psychosis: Quantile Regression. JAMA Psychiatry 2016, 73: 1094-1095. PMID: 27580422, DOI: 10.1001/jamapsychiatry.2016.2013.Peer-Reviewed Original Research
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFES
2013
Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies
2012
Is Early Intervention for Psychosis Feasible and Effective?
Srihari VH, Shah J, Keshavan MS. Is Early Intervention for Psychosis Feasible and Effective? Psychiatric Clinics Of North America 2012, 35: 613-631. PMID: 22929869, PMCID: PMC3431510, DOI: 10.1016/j.psc.2012.06.004.Peer-Reviewed Original Research
2010
Mediators and moderators in early intervention research
Breitborde NJ, Srihari VH, Pollard JM, Addington DN, Woods SW. Mediators and moderators in early intervention research. Early Intervention In Psychiatry 2010, 4: 143-152. PMID: 20536970, PMCID: PMC4469902, DOI: 10.1111/j.1751-7893.2010.00177.x.Peer-Reviewed Original Research
2009
Review of the operational definition for first‐episode psychosis
Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first‐episode psychosis. Early Intervention In Psychiatry 2009, 3: 259-265. PMID: 22642728, PMCID: PMC4451818, DOI: 10.1111/j.1751-7893.2009.00148.x.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisDuration of psychosisEarly psychosis patientsAntipsychotic medication useFirst treatment contactRecent-onset psychosisMedication usePsychosis patientsTreatment contactPsychotic illnessClinical servicesPsychosisIllnessResearch settingsDurationOperational definitionTreatmentReviewPatientsSelective reviewIndividualsMultifamily Psychoeducation for First-Episode Psychosis: A Cost-Effectiveness Analysis
Breitborde NJ, Woods SW, Srihari VH. Multifamily Psychoeducation for First-Episode Psychosis: A Cost-Effectiveness Analysis. Psychiatric Services 2009, 60: 1477-1483. PMID: 19880465, PMCID: PMC5594750, DOI: 10.1176/ps.2009.60.11.1477.Peer-Reviewed Original Research
2002
Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia
Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, Kerr D, Leone P, Krystal JH, Spencer DD, During MJ, Sherwin RS. Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 271-279. PMID: 11891432, DOI: 10.1097/00004647-200203000-00004.Peer-Reviewed Original ResearchConceptsConscious human subjectsBrain extracellular fluidLactate levelsECF levelsExtracellular fluidBasal conditionsGlucose-derived lactateEffects of hyperglycemiaHuman subjectsECF glucoseElectrophysiologic evaluationIntracerebral microdialysisIntractable epilepsyBrain levelsMetabolic milieuClamp studiesBrainAnaerobic glycolysisHuman dataLactateGlucoseLow levelsSubjectsHigh levelsLevels