2018
Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression
Correll CU, Galling B, Pawar A, Krivko A, Bonetto C, Ruggeri M, Craig TJ, Nordentoft M, Srihari VH, Guloksuz S, Hui CLM, Chen EYH, Valencia M, Juarez F, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, Marcy P, Addington J, Estroff SE, Robinson J, Penn D, Severe JB, Kane JM. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Psychiatry 2018, 75: 555-565. PMID: 29800949, PMCID: PMC6137532, DOI: 10.1001/jamapsychiatry.2018.0623.Peer-Reviewed Original ResearchConceptsEarly phase psychosisEarly intervention servicesCause treatment discontinuationSchizophrenia spectrum disordersSymptom severityTreatment discontinuationPsychiatric hospitalizationSystematic reviewIntervention servicesMonths of treatmentEnd of treatmentFirst-episode psychosisTotal symptom severitySystematic literature searchMeta-regression analysisPositive symptom severityCoprimary outcomesPrespecified subgroupsLanguage restrictionsNegative symptom severityClinical trialsTreatment periodMAIN OUTCOMESpectrum disorderPRISMA guidelines
2015
Too Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis
van Schalkwyk GI, Davidson L, Srihari V. Too Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis. Psychiatric Quarterly 2015, 86: 521-532. PMID: 25663602, PMCID: PMC5576358, DOI: 10.1007/s11126-015-9348-4.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultFemaleHumansMaleNarrationPsychotic DisordersSeverity of Illness IndexThematic Apperception TestConceptsFirst episode psychosis programLong-term outcomesSpecialized treatment servicesOnset of psychosisInitial contactSpecialized servicesYounger patientsSignificant morbidityPsychosis programPatient preferencesEarly treatmentEffective treatmentEarly psychosisPsychiatric careTreatment experienceTreatment prioritiesPsychotic disordersTreatment servicesPatientsInductive thematic analysisFurther treatmentTreatmentDisproportionate improvementBehavioral changesCritical period
2012
Is Early Intervention for Psychosis Feasible and Effective?
Srihari VH, Shah J, Keshavan MS. Is Early Intervention for Psychosis Feasible and Effective? Psychiatric Clinics Of North America 2012, 35: 613-631. PMID: 22929869, PMCID: PMC3431510, DOI: 10.1016/j.psc.2012.06.004.Peer-Reviewed Original ResearchDisease ProgressionHumansPrognosisPsychotic DisordersSchizophreniaSeverity of Illness IndexTime FactorsTreatment Outcome
2011
Insomnia is frequent in schizophrenia and associated with night eating and obesity
Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophrenia Research 2011, 133: 238-243. PMID: 21856129, PMCID: PMC5581545, DOI: 10.1016/j.schres.2011.07.030.Peer-Reviewed Original ResearchConceptsBody mass indexQuality of lifeSleep difficultiesMass indexClinical insomniaSevere insomniaNight eatingPoor sleepPsychiatric symptomsTypes of antipsychoticsPrevalence of insomniaRelationship of sleepProminent clinical concernBrief cognitive assessmentIndependent predictorsPoint prevalenceClinical variablesClinical careSleep patternsSchizoaffective disorderClinical concernInsomniaLow qualityWeight gainSchizophrenia
2009
Cognitive Behavior Therapy for Early Psychosis: A Comprehensive Review of Individual vs. Group Treatment Studies
Saksa JR, Cohen SJ, Srihari VH, Woods SW. Cognitive Behavior Therapy for Early Psychosis: A Comprehensive Review of Individual vs. Group Treatment Studies. International Journal Of Group Psychotherapy 2009, 59: 357-383. PMID: 19548785, DOI: 10.1521/ijgp.2009.59.3.357.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyHumansPsychotherapy, GroupPsychotic DisordersSchizophreniaSeverity of Illness IndexTreatment OutcomeConceptsGroup cognitive behavior therapyCognitive behavior therapyEarly psychosisEarly casesModest treatment benefitsGroup of patientsBehavior therapyYounger patientsGroup treatment studyTreatment benefitPatient uncertaintyEffective modalityTreatment studiesPsychosisPatientsTherapyOutcomesRecent studiesCurrent studyIllnessComprehensive review