2022
Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia
Goetzl EJ, Srihari VH, Mustapic M, Kapogiannis D, Heninger GR. Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron‐derived extracellular vesicles of early schizophrenia. The FASEB Journal 2022, 36: e22466. PMID: 35867070, PMCID: PMC9358927, DOI: 10.1096/fj.202200792rr.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesChannel proteinsExtracellular vesiclesGenome-wide association studiesMitochondrial ion channelsIon channel proteinsIndividual proteinsLeucine zipperAssociation studiesMitochondrial NaMitochondrial levelTransient receptor potential cation channelMitochondrial Ca2Ion channelsSequence studiesProteinMember B1Extracted proteinsCation channelsNeuronal functionΑ-1CMember 4Calcium homeostasisVesiclesStructural alterations
2021
Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis
Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR. Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis. The FASEB Journal 2021, 35: e21339. PMID: 33454965, DOI: 10.1096/fj.202002519r.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesFunctional proteinsMitochondrial functional proteinsMitochondrial protein mitofusin 2Extracellular vesiclesMitochondrial ATP synthaseMitochondrial ATP synthase activityATP synthase activityTranscription factor AMitochondrial proteinsATP synthaseMyosin VICyclophilin DConversion of NADHMitofusin 2EV contentExosome markersPeptide humaninProteinMitochondrial impairmentSynthase activityProtein levelsFactor AMitochondriaVesicles