2021
First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care
Ferrara M, Guloksuz S, Mathis WS, Li F, Lin IH, Syed S, Gallagher K, Shah J, Kline E, Tek C, Keshavan M, Srihari VH. First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care. Social Psychiatry And Psychiatric Epidemiology 2021, 56: 1359-1369. PMID: 33948678, PMCID: PMC8319102, DOI: 10.1007/s00127-021-02090-0.Peer-Reviewed Original ResearchConceptsPsychosis onsetNon-affective psychosisPsychosis risk syndromeEarly detection effortsAversive eventsAversive pathwaysProdromal sampleClinical characteristicsAntipsychotic treatmentEffective treatmentSociodemographic characteristicsSpecialized treatmentPsychosisProdromeOnsetTreatmentStructured interviewsOverall functioningFamily membersMeasures of delayEpisodesNew HavenSemi-structured interviewsHelp seekersPathway
2020
Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation
Srihari V, Cahill J. Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation. 2020, 191-210. DOI: 10.7551/mitpress/13412.003.0018.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeKnowledge translationClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyBiological mechanismsSchizophreniaOutcomesTreatmentHealthIllnessStagingEpidemiologyH. ChenDeveloping and Implementing Tools for Prevention and Early Intervention
Torous J, Chanen A, Chen E, Do K, Heinssen R, McGorry P, Nordentoft M, Schoenbaum M, Srihari V, Verma S. Developing and Implementing Tools for Prevention and Early Intervention. 2020, 211-234. DOI: 10.7551/mitpress/13412.003.0019.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyKnowledge translationBiological mechanismsPreventionOutcomesTreatmentHealthIllnessStagingEpidemiologyH. Chen
2018
Development and validation of the client engagement and service use scale: A pilot study
Kline ER, DeTore NR, Keefe K, Seidman LJ, Srihari VH, Keshavan MS, Guyer M. Development and validation of the client engagement and service use scale: A pilot study. Schizophrenia Research 2018, 201: 343-346. PMID: 29764759, DOI: 10.1016/j.schres.2018.05.006.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisEpisode psychosisService utilizationPilot studyService Engagement ScaleMultiple intervention componentsClients' service utilizationClient engagementMedication adherenceSpecialty careEarly treatmentInter-rater reliabilitySession attendanceHigh inter-rater reliabilityTreatment teamIntervention componentsSpecialized treatmentMenu of servicesPreliminary evidenceCliniciansPsychosisConsumer advocacy groupsUse ScaleTreatmentMinimal trainingTransforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
Dixon LB, Goldman HH, Srihari VH, Kane JM. Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative. Annual Review Of Clinical Psychology 2018, 14: 1-22. PMID: 29328779, PMCID: PMC8990328, DOI: 10.1146/annurev-clinpsy-050817-084934.Peer-Reviewed Original ResearchConceptsCoordinated Specialty CareInitial Schizophrenia Episode projectExtensive functional impairmentPatient Outcomes Research TeamTreatment of schizophreniaSchizophrenia spectrum disordersEvidence-based practiceUntreated psychosisSpecialty careChronic schizophreniaCSC programsEpisode ProjectFunctional impairmentLifetime prevalenceRAISE studyRecovery of individualsTreatment settingsEarly interventionNeurodevelopmental illnessSchizophreniaTreatmentUnited StatesInternational studiesSpectrum disorderPatients
2015
Too Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis
van Schalkwyk GI, Davidson L, Srihari V. Too Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis. Psychiatric Quarterly 2015, 86: 521-532. PMID: 25663602, PMCID: PMC5576358, DOI: 10.1007/s11126-015-9348-4.Peer-Reviewed Original ResearchConceptsFirst episode psychosis programLong-term outcomesSpecialized treatment servicesOnset of psychosisInitial contactSpecialized servicesYounger patientsSignificant morbidityPsychosis programPatient preferencesEarly treatmentEffective treatmentEarly psychosisPsychiatric careTreatment experienceTreatment prioritiesPsychotic disordersTreatment servicesPatientsInductive thematic analysisFurther treatmentTreatmentDisproportionate improvementBehavioral changesCritical period
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFES
2009
Review of the operational definition for first‐episode psychosis
Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first‐episode psychosis. Early Intervention In Psychiatry 2009, 3: 259-265. PMID: 22642728, PMCID: PMC4451818, DOI: 10.1111/j.1751-7893.2009.00148.x.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisDuration of psychosisEarly psychosis patientsAntipsychotic medication useFirst treatment contactRecent-onset psychosisMedication usePsychosis patientsTreatment contactPsychotic illnessClinical servicesPsychosisIllnessResearch settingsDurationOperational definitionTreatmentReviewPatientsSelective reviewIndividuals