2024
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Wannan C, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker J, Bearden C, Billah T, Bouix S, Broome M, Buccilli K, Cadenhead K, Calkins M, Cannon T, Cecci G, Chen E, Cho K, Choi J, Clark S, Coleman M, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Dwyer D, Ebdrup B, Ellman L, Fusar-Poli P, Galindo L, Gaspar P, Gerber C, Glenthøj L, Glynn R, Harms M, Horton L, Kahn R, Kambeitz J, Kambeitz-Ilankovic L, Kane J, Kapur T, Keshavan M, Kim S, Koutsouleris N, Kubicki M, Kwon J, Langbein K, Lewandowski K, Light G, Mamah D, Marcy P, Mathalon D, McGorry P, Mittal V, Nordentoft M, Nunez A, Pasternak O, Pearlson G, Perez J, Perkins D, Powers A, Roalf D, Sabb F, Schiffman J, Shah J, Smesny S, Spark J, Stone W, Strauss G, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum I, Wolf D, Wolff P, Wood S, Yung A, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrión R, Castro E, Cetin-Karayumak S, Chakravarty M, Cho Y, Cotter D, D’Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur R, Gur R, Hamilton H, Hoftman G, Jacobs G, Jarcho J, Ji J, Kohler C, Lalousis P, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas S, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt D, Rabin R, Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari V, Srivastava A, Thompson A, Turetsky B, Walsh B, Whitford T, Wigman J, Yao B, Yuen H, Ahmed U, Byun A, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek S, Bates K, Bathery A, Bayer J, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi R, Chen J, Cheng N, Ching A, Clifford C, Colton B, Contreras P, Corral S, Damiani S, Done M, Estradé A, Etuka B, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui C, Suen Y, Wong S, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Fariña G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods S, Shenton M. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, 50: 496-512. PMID: 38451304, PMCID: PMC11059785, DOI: 10.1093/schbul/sbae011.Peer-Reviewed Original ResearchClinical high-risk individualsClinical high riskNational Institute of Mental HealthInstitute of Mental HealthAttenuated positive symptomsPersistent negative symptomsTransition to psychosisCHR statusHigh riskNegative symptomsPositive symptomsAnxiety symptomsPsychosocial functioningCognitive dataOutcomes of individualsDigital health technologiesDaily surveysPsychosisSCZPublic health needsMental healthNovel pharmacological interventionsSchizophreniaClinical outcomesHealth needs
2023
Towards a youth mental health paradigm: a perspective and roadmap
Uhlhaas P, Davey C, Mehta U, Shah J, Torous J, Allen N, Avenevoli S, Bella-Awusah T, Chanen A, Chen E, Correll C, Do K, Fisher H, Frangou S, Hickie I, Keshavan M, Konrad K, Lee F, Liu C, Luna B, McGorry P, Meyer-Lindenberg A, Nordentoft M, Öngür D, Patton G, Paus T, Reininghaus U, Sawa A, Schoenbaum M, Schumann G, Srihari V, Susser E, Verma S, Woo T, Yang L, Yung A, Wood S. Towards a youth mental health paradigm: a perspective and roadmap. Molecular Psychiatry 2023, 28: 3171-3181. PMID: 37580524, PMCID: PMC10618105, DOI: 10.1038/s41380-023-02202-z.Peer-Reviewed Original ResearchConceptsMental disordersSevere mental disordersEarly intervention paradigmYears of ageMost mental disordersEarly diagnosisEmergence of psychopathologyClinical careTypical onsetProtective factorsBrain developmentMental healthDiagnosisDisordersHealth paradigmMental health paradigmPsychopathologyIntervention paradigmPathogenesisYoung peopleCarePrevention
2020
Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation
Srihari V, Cahill J. Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation. 2020, 191-210. DOI: 10.7551/mitpress/13412.003.0018.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeKnowledge translationClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyBiological mechanismsSchizophreniaOutcomesTreatmentHealthIllnessStagingEpidemiologyH. ChenDeveloping and Implementing Tools for Prevention and Early Intervention
Torous J, Chanen A, Chen E, Do K, Heinssen R, McGorry P, Nordentoft M, Schoenbaum M, Srihari V, Verma S. Developing and Implementing Tools for Prevention and Early Intervention. 2020, 211-234. DOI: 10.7551/mitpress/13412.003.0019.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyKnowledge translationBiological mechanismsPreventionOutcomesTreatmentHealthIllnessStagingEpidemiologyH. Chen
2009
Public-academic partnerships: early intervention for psychotic disorders in a community mental health center.
Srihari VH, Breitborde NJ, Pollard J, Tek C, Hyman L, Frisman LK, McGlashan TH, Jacobs S, Woods SW. Public-academic partnerships: early intervention for psychotic disorders in a community mental health center. Psychiatric Services 2009, 60: 1426-8. PMID: 19880454, PMCID: PMC4469899, DOI: 10.1176/appi.ps.60.11.1426.Peer-Reviewed Original ResearchConceptsMental health centersEarly interventionHealth centersConnecticut Mental Health CenterCommunity mental health centerLong-term outcomesEarly intervention servicesYounger patientsUntreated illnessPsychotic illnessPsychotic disordersAddiction servicesSpecialized treatmentMental healthInterventionConnecticut DepartmentIllnessPatientsPsychosis