2018
Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis
Fryer SL, Roach BJ, Ford JM, Donaldson KR, Calhoun VD, Pearlson GD, Kiehl KA, Srihari VH, McGlashan TH, Woods SW, Mathalon DH. Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis. Schizophrenia Bulletin 2018, 45: 158-168. PMID: 29385625, PMCID: PMC6293268, DOI: 10.1093/schbul/sbx198.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high riskESZ groupsBilateral dorsal anterior cingulateResponse inhibitionGo/NoGo task performanceEarly illness schizophreniaInhibitory control regionsVariable motor responseTask-based functional connectivityFunctional connectivity relationshipsDorsal anterior cingulateMedial prefrontal cortexDefault mode network regionsInferior frontal cortexRight inferior frontal regionsFunctional magnetic resonanceFrontal cortexHigh riskHealthy adolescentsSchizophrenia patientsAnterior cingulateControl groupInferior frontal regionsCHR group
2013
Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis
Fryer SL, Woods SW, Kiehl KA, Calhoun VD, Pearlson GD, Roach BJ, Ford JM, Srihari VH, McGlashan TH, Mathalon DH. Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis. Frontiers In Psychiatry 2013, 4: 92. PMID: 24032017, PMCID: PMC3768116, DOI: 10.3389/fpsyt.2013.00092.Peer-Reviewed Original ResearchHealthy controlsDefault mode networkPsychosis onsetDMN regionsSeed-based connectivity analysisEarly schizophrenia patientsDMN suppressionClinical high riskLoad-dependent increaseMedial prefrontal cortexPosterior DMN nodesSuppression of activityPosterior parietal cortexResting-state fMRI dataDorsolateral prefrontal cortex activationDeficient suppressionESZ groupsESZ patientsPrefrontal cortex activationHigh riskEarly psychosisSchizophrenia patientsCHR individualsCortex activationLoad-dependent modulation