2023
Towards a youth mental health paradigm: a perspective and roadmap
Uhlhaas P, Davey C, Mehta U, Shah J, Torous J, Allen N, Avenevoli S, Bella-Awusah T, Chanen A, Chen E, Correll C, Do K, Fisher H, Frangou S, Hickie I, Keshavan M, Konrad K, Lee F, Liu C, Luna B, McGorry P, Meyer-Lindenberg A, Nordentoft M, Öngür D, Patton G, Paus T, Reininghaus U, Sawa A, Schoenbaum M, Schumann G, Srihari V, Susser E, Verma S, Woo T, Yang L, Yung A, Wood S. Towards a youth mental health paradigm: a perspective and roadmap. Molecular Psychiatry 2023, 28: 3171-3181. PMID: 37580524, PMCID: PMC10618105, DOI: 10.1038/s41380-023-02202-z.Peer-Reviewed Original ResearchConceptsMental disordersSevere mental disordersEarly intervention paradigmYears of ageMost mental disordersEarly diagnosisEmergence of psychopathologyClinical careTypical onsetProtective factorsBrain developmentMental healthDiagnosisDisordersHealth paradigmMental health paradigmPsychopathologyIntervention paradigmPathogenesisYoung peopleCarePrevention
2022
Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis
Han GT, Trevisan DA, Foss-Feig J, Srihari V, McPartland JC. Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis. Journal Of Autism And Developmental Disorders 2022, 53: 3636-3647. PMID: 35752729, PMCID: PMC10202012, DOI: 10.1007/s10803-022-05620-0.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSocial communication difficultiesSymptom networksCognitive-perceptual symptomsSpectrum disorderRepetitive behaviorsNeurodevelopmental conditionsCommunication difficultiesASDPotential treatment targetAutismSymptom network structureDiagnostic groupsTreatment targetsNetwork analysis approachHigh centralitySymptomatologySchizophreniaSymptomsOrganizationAdultsDisordersBayesian network analysisDifficultiesAnalysis approach
2021
Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia
Levy E, Isenstein E, Foss-Feig J, Srihari V, Anticevic A, Naples A, McPartland J. Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia. Review Journal Of Autism And Developmental Disorders 2021, 9: 521-554. PMID: 36568688, PMCID: PMC9783109, DOI: 10.1007/s40489-021-00260-z.Peer-Reviewed Original ResearchAutism spectrum disorderEvent-related potentialsSchizophrenia spectrum disordersSpectrum disorderFacial communicationResearch Domain Criteria frameworkSocial cognitionHeterogeneous clinical populationN170 latencySocial perceptionTransdiagnostic researchClinical populationsNeural activitySZ populationInconsistent findingsNeurodevelopmental disordersN170Criteria frameworkResearch findingsAreas of overlapDisordersN250CognitionElectrophysiological studiesPerception
2020
Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation
Srihari V, Cahill J. Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation. 2020, 191-210. DOI: 10.7551/mitpress/13412.003.0018.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeKnowledge translationClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyBiological mechanismsSchizophreniaOutcomesTreatmentHealthIllnessStagingEpidemiologyH. ChenDeveloping and Implementing Tools for Prevention and Early Intervention
Torous J, Chanen A, Chen E, Do K, Heinssen R, McGorry P, Nordentoft M, Schoenbaum M, Srihari V, Verma S. Developing and Implementing Tools for Prevention and Early Intervention. 2020, 211-234. DOI: 10.7551/mitpress/13412.003.0019.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyKnowledge translationBiological mechanismsPreventionOutcomesTreatmentHealthIllnessStagingEpidemiologyH. Chen
2017
Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderFunctional magnetic resonance imagingRecent theoretical accountsEarly course schizophreniaNeurodevelopmental disordersPharmacological challenge studiesNeural correlatesNeuroscience literatureTheoretical accountsNeural circuitryTheoretical neuroscienceNoninvasive neuroimagingBehavioral dysfunctionFuture researchNeuropsychiatric conditionsComputational modelSchizophreniaProton magnetic resonance spectroscopyDisordersInhibition imbalanceMagnetic resonance imagingDistinct modalitiesPoint of convergenceInhibition balance
2011
Hoofbeats and zebras: neurodegenerative disorder presenting as a “first episode” of psychosis
Ozkan B, Phutane V, Jonas E, Tek C, Srihari V. Hoofbeats and zebras: neurodegenerative disorder presenting as a “first episode” of psychosis. General Hospital Psychiatry 2011, 33: 412.e1-412.e3. PMID: 21762843, PMCID: PMC3139144, DOI: 10.1016/j.genhosppsych.2011.03.011.Peer-Reviewed Original ResearchConceptsNeurodegenerative disordersDiverse neuropsychiatric symptomsBrain magnetic resonanceProgressive cortical atrophyCortical atrophyPsychosis clinicNeuropsychiatric symptomsFirst episodeFrontal lobeAuditory hallucinationsBehavioral declineDisordersParanoid ideationMagnetic resonancePatientsAtrophyClinicSymptomsPsychosisHallucinations
2006
Revisiting cycloid psychosis: A case of an acute, transient and recurring psychotic disorder
Srihari VH, Lee TS, Rohrbaugh RM, D'Souza DC. Revisiting cycloid psychosis: A case of an acute, transient and recurring psychotic disorder. Schizophrenia Research 2006, 82: 261-264. PMID: 16442782, DOI: 10.1016/j.schres.2005.11.022.Peer-Reviewed Original ResearchConceptsPsychotic disordersCycloid psychosisTransient psychotic disordersICD-10 categoriesIV-TR criteriaMinimal functional impairmentFavorable prognosisRecurrent psychosisUnknown incidenceDistinct pathophysiologyFunctional impairmentClinical attentionPsychosisDisordersFurther investigationPrognosisPathophysiologyIncidenceCasesImpairment