2009
IFN-β Inhibits Human Th17 Cell Differentiation
Ramgolam V, Sha Y, Jin J, Zhang X, Markovic-Plese S. IFN-β Inhibits Human Th17 Cell Differentiation. The Journal Of Immunology 2009, 183: 5418-5427. PMID: 19783688, DOI: 10.4049/jimmunol.0803227.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedDendritic CellsDown-RegulationHumansInterferon beta-1aInterferon-betaInterleukin-10Interleukin-12 Subunit p35Interleukin-17Interleukin-1betaInterleukin-23 Subunit p19Multiple SclerosisNuclear Receptor Subfamily 1, Group F, Member 3PhosphorylationReceptors, CCR6Receptors, InterleukinReceptors, Retinoic AcidReceptors, Thyroid HormoneSTAT1 Transcription FactorSTAT3 Transcription FactorT-Lymphocytes, Helper-InducerUp-RegulationConceptsTh17 cell differentiationDendritic cellsMultiple sclerosisT cellsReceptor CIL-17AAutoimmune responseIL-1betaIFN beta-1a treatmentRelapsing-remitting multiple sclerosisIL-10 gene expressionTh17 cell markersUntreated MS patientsCNS inflammatory diseasesIL-10 secretionNaive T cellsTh17-polarizing conditionsEffect of IFNCell differentiationIL-27p28 expressionPrimary therapySuppressor of cytokineIL-17IL-23IL-23p19
2008
Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes
Zhang X, Jin J, Peng X, Ramgolam V, Markovic-Plese S. Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes. The Journal Of Immunology 2008, 180: 6988-6996. PMID: 18453621, DOI: 10.4049/jimmunol.180.10.6988.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCD4-Positive T-LymphocytesCytokinesEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGene ExpressionHumansImmunologic FactorsInterleukin-17MaleMonocytesMultiple SclerosisNuclear ProteinsOligonucleotide Array Sequence AnalysisReceptors, Cytoplasmic and NuclearReverse Transcriptase Polymerase Chain ReactionSimvastatinSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Lymphocyte SubsetsConceptsAutoimmune responseMultiple sclerosisImmunomodulatory mechanismsT cellsIL-23 gene expressionTranscription factor RORCIL-17 productionIL-17 secretionIL-27 productionChronic inflammatory diseaseNovel immunomodulatory mechanismGood safety profileIL-17 transcriptionPromising therapeutic approachCholesterol-lowering agentsHuman autoimmune responseImmunomodulatory agentsSafety profileAutoimmune diseasesIL-6IL-4Inflammatory diseasesSpecific effectsTherapeutic approachesIFN-gamma