Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes
Zhang X, Jin J, Peng X, Ramgolam V, Markovic-Plese S. Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes. The Journal Of Immunology 2008, 180: 6988-6996. PMID: 18453621, DOI: 10.4049/jimmunol.180.10.6988.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCD4-Positive T-LymphocytesCytokinesEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGene ExpressionHumansImmunologic FactorsInterleukin-17MaleMonocytesMultiple SclerosisNuclear ProteinsOligonucleotide Array Sequence AnalysisReceptors, Cytoplasmic and NuclearReverse Transcriptase Polymerase Chain ReactionSimvastatinSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Lymphocyte SubsetsConceptsAutoimmune responseMultiple sclerosisImmunomodulatory mechanismsT cellsIL-23 gene expressionTranscription factor RORCIL-17 productionIL-17 secretionIL-27 productionChronic inflammatory diseaseNovel immunomodulatory mechanismGood safety profileIL-17 transcriptionPromising therapeutic approachCholesterol-lowering agentsHuman autoimmune responseImmunomodulatory agentsSafety profileAutoimmune diseasesIL-6IL-4Inflammatory diseasesSpecific effectsTherapeutic approachesIFN-gammaDegenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis
Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, Markovic‐Plese S. Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis. European Journal Of Immunology 2008, 38: 1297-1309. PMID: 18412170, DOI: 10.1002/eji.200737519.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid SequenceAutoimmunityClone CellsEpitopes, T-LymphocyteHLA-DR2 AntigenHumansInterferon-gammaInterleukin-17Interleukin-4Leukocytes, MononuclearLymphocyte ActivationMiddle AgedMultiple Sclerosis, Relapsing-RemittingMyelin Basic ProteinMyelin ProteinsMyelin Proteolipid ProteinMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsPeptidesReceptors, Antigen, T-CellT-Lymphocyte SubsetsT-LymphocytesConceptsMultiple sclerosisAutoimmune responseT cellsProliferative responseTCR degeneracyMHC class II allelesAutoreactive T cellsClass II allelesT cell activationMyelin peptidesMS patientsDR2 allelesHealthy controlsReactive cellsStimulatory potencyCell activationTCR recognitionCaucasian populationContext of diseaseSclerosisDR2aCellsILTCRPeptides