2010
Interferon-beta inhibits Th17 cell differentiation in patients with multiple sclerosis.
Ramgolam V, Markovic-Plese S. Interferon-beta inhibits Th17 cell differentiation in patients with multiple sclerosis. Endocrine Metabolic & Immune Disorders - Drug Targets 2010, 10: 161-7. PMID: 20384573, DOI: 10.2174/187153010791213029.Peer-Reviewed Original ResearchConceptsDendritic cellsT cellsB cellsMultiple sclerosisCell-mediated autoimmune responseRetinoic acid-related orphan receptorTranscription factor retinoic acid-related orphan receptorAcid-related orphan receptorCytokines IL-17AFirst-line therapyCytokines IL-1bInduction of suppressorCell differentiationMechanism of actionRR-MSIL-17AIL-23Th17 cellsIL-10Immunoregulatory mechanismsIL-12Autoimmune responseAutoimmune diseasesCytokines interleukinChemokine receptors
2009
IFN-β Inhibits Human Th17 Cell Differentiation
Ramgolam V, Sha Y, Jin J, Zhang X, Markovic-Plese S. IFN-β Inhibits Human Th17 Cell Differentiation. The Journal Of Immunology 2009, 183: 5418-5427. PMID: 19783688, DOI: 10.4049/jimmunol.0803227.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedDendritic CellsDown-RegulationHumansInterferon beta-1aInterferon-betaInterleukin-10Interleukin-12 Subunit p35Interleukin-17Interleukin-1betaInterleukin-23 Subunit p19Multiple SclerosisNuclear Receptor Subfamily 1, Group F, Member 3PhosphorylationReceptors, CCR6Receptors, InterleukinReceptors, Retinoic AcidReceptors, Thyroid HormoneSTAT1 Transcription FactorSTAT3 Transcription FactorT-Lymphocytes, Helper-InducerUp-RegulationConceptsTh17 cell differentiationDendritic cellsMultiple sclerosisT cellsReceptor CIL-17AAutoimmune responseIL-1betaIFN beta-1a treatmentRelapsing-remitting multiple sclerosisIL-10 gene expressionTh17 cell markersUntreated MS patientsCNS inflammatory diseasesIL-10 secretionNaive T cellsTh17-polarizing conditionsEffect of IFNCell differentiationIL-27p28 expressionPrimary therapySuppressor of cytokineIL-17IL-23IL-23p19