2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2015
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaVeterans Aging Cohort StudyVACS IndexCAP outcomesAntiretroviral therapyOlder adultsHigher VACS indexDays of dischargeAging Cohort StudyUninfected participantsCohort studyMean LOSHIV infectionLonger LOSClinical outcomesUnadjusted analysesUninfected groupMultivariable modelEligibility criteriaHIVMale veteransMortality rateART useMortalityOutcomes
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseOutcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era.
Malinis MF, Chen S, Allore HG, Quagliarello VJ. Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era. Annals Of Transplantation 2014, 19: 478-87. PMID: 25256592, PMCID: PMC4201657, DOI: 10.12659/aot.890934.Peer-Reviewed Original ResearchConceptsFunctional statusHepatitis CDonor ageHepatocellular carcinomaLT recipientsMELD eraAge 50End‐stage liver disease eraFive-year graft survival ratesEnd-stage liver disease (MELD) scoreSurvival rateAdult liver transplantation recipientsStage liver disease scoreLong-term graft survivalCox proportional hazard modelingHazard modelingPre-MELD eraGraft survival ratesLiver Disease scoreRetrospective cohort studyLiver transplantation recipientsLong-term graftModifiable risk factorsAdult LT recipientsShort-term outcomes
2013
Trends in Hospitalization Rates and Outcomes of Endocarditis Among Medicare Beneficiaries
Bikdeli B, Wang Y, Kim N, Desai MM, Quagliarello V, Krumholz HM. Trends in Hospitalization Rates and Outcomes of Endocarditis Among Medicare Beneficiaries. Journal Of The American College Of Cardiology 2013, 62: 2217-2226. PMID: 23994421, PMCID: PMC4335801, DOI: 10.1016/j.jacc.2013.07.071.Peer-Reviewed Original ResearchModifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2012
The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients
Ledizet M, Murray TS, Puttagunta S, Slade MD, Quagliarello VJ, Kazmierczak BI. The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients. PLOS ONE 2012, 7: e49578. PMID: 23152923, PMCID: PMC3495863, DOI: 10.1371/journal.pone.0049578.Peer-Reviewed Original ResearchConceptsP. aeruginosa infectionAeruginosa infectionBacterial factorsHospitalized patientsUrinary tractPositive P. aeruginosa culturesP. aeruginosaUrinary tract cathetersP. aeruginosa isolatesLogistic regression modelsPseudomonas aeruginosaProspective cohortDiabetes mellitusSubgroup analysisClinical dataTreatment decisionsClinical diseaseAeruginosa isolatesAnimal modelsPatientsClinical sitesFactor expressionInfectionHost factorsP. aeruginosa culturesEfficacy and effectiveness as aspects of cluster randomized trials with nursing home residents: Methodological insights from a pneumonia prevention trial
Van Ness PH, Peduzzi PN, Quagliarello VJ. Efficacy and effectiveness as aspects of cluster randomized trials with nursing home residents: Methodological insights from a pneumonia prevention trial. Contemporary Clinical Trials 2012, 33: 1124-1131. PMID: 22917599, PMCID: PMC3468687, DOI: 10.1016/j.cct.2012.08.004.Peer-Reviewed Original ResearchConceptsNursing home residentsNursing homesHome residentsPneumonia preventionClinical trialsLong-term care nursing home residentsChlorhexidine oral rinseInadequate oral careNursing home clustersSame nursing homeHome intervention studyOral carePrevention trialsOral rinseSwallowing difficultiesRisk factorsMulticomponent interventionIntervention studiesElders trialOngoing clusterCluster randomizationClinical researchStudy efficacyDifferent interventionsTrials
2009
Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents
Quagliarello V, Juthani‐Mehta M, Ginter S, Towle V, Allore H, Tinetti M. Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents. Journal Of The American Geriatrics Society 2009, 57: 1226-1231. PMID: 19558483, PMCID: PMC2779042, DOI: 10.1111/j.1532-5415.2009.02311.x.Peer-Reviewed Original ResearchConceptsNursing home residentsChlorhexidine oral rinseOral brushingHome residentsOral hygieneStaff adherenceOral rinseIntervention protocolImproved oral hygienePneumonia risk factorsRisk factor reductionPlaque score reductionPrevent PneumoniaChlorhexidine rinseProspective studyRisk factorsScore reductionNursing homesSwallowing techniquesAdherenceBrushingFactor reductionPneumoniaHygieneMonthsClinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRisk
2007
Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*
Juthani‐Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*. Journal Of The American Geriatrics Society 2007, 55: 1072-1077. PMID: 17608881, DOI: 10.1111/j.1532-5415.2007.01217.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsNegative predictive valuePositive predictive valueConsensus-based criteriaLaboratory evidenceHome residentsTract infectionsPredictive valueEvidence-based clinical criteriaDiagnostic accuracyProspective cohort studySimilar test characteristicsMcGeer criteriaUTI criteriaCohort studyProspective surveillanceUrine cultureClinical criteriaNursing homesTest characteristicsInfectionLoeb criteriaParticipantsSpecificity
2005
Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections
Juthani‐Mehta M, Drickamer MA, Towle V, Zhang Y, Tinetti ME, Quagliarello VJ. Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections. Journal Of The American Geriatrics Society 2005, 53: 1986-1990. PMID: 16274383, DOI: 10.1111/j.1532-5415.2005.00470.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsTract infectionsLaboratory criteriaHome residentsDiagnostic criteriaClinical practiceConsensus criteriaInfection control practitionersFirst diagnostic stepMcGeer criteriaNoncatheterized patientsUrine cultureProspective dataMental statusNineteen physiciansSurveillance criteriaNursing homesPrevention strategiesSelf-administered surveyDipstick analysisDiagnostic stepsPhysician assistantsCharge nursesNurses
2001
Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death
McMillan D, Lin C, Aronin S, Quagliarello V. Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death. Clinical Infectious Diseases 2001, 33: 969-975. PMID: 11528567, DOI: 10.1086/322612.Peer-Reviewed Original ResearchConceptsCommunity-acquired bacterial meningitisBacterial meningitisTiming of deathImmediate causeSurvival end pointsWorld Health OrganizationMeningitisHealth StatisticsEnd pointUnderlying causeCategorization of causesHealth OrganizationDeathSubstantial proportionCategory IIIPatientsCategory IIAdultsCauseCategory IHospitalizationUtility of prognostic stratification in adults with community-acquired bacterial meningitis
Aronin S, Quagliarello V. Utility of prognostic stratification in adults with community-acquired bacterial meningitis. Comprehensive Therapy 2001, 27: 72-77. PMID: 11280860, DOI: 10.1007/s12019-001-0011-7.Peer-Reviewed Original Research
1999
A prognostic rule for elderly patients admitted with community-acquired pneumonia
Conte H, Chen Y, Mehal W, Phil D, Scinto J, Quagliarello V. A prognostic rule for elderly patients admitted with community-acquired pneumonia. The American Journal Of Medicine 1999, 106: 20-28. PMID: 10320113, DOI: 10.1016/s0002-9343(98)00369-6.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaElderly patientsDerivation cohortValidation cohortStaging systemHeterogeneous adult populationAdult populationHospital mortality ratePrognostic staging systemVital sign abnormalitiesHospital mortalityCreatinine levelsIndependent predictorsMultivariable analysisPrognostic stratificationAdmission characteristicsPneumoniaMortality ratePatientsCohortPrognostic rulesMotor responseMortalityGreater overall accuracyAdmission
1996
Acute meningitis with a negative gram's stain: Clinical and management outcomes in 171 episodes
Elmore J, Horwitz R, Quagliarello V. Acute meningitis with a negative gram's stain: Clinical and management outcomes in 171 episodes. The American Journal Of Medicine 1996, 100: 78-84. PMID: 8579091, DOI: 10.1016/s0002-9343(96)90015-7.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAnti-Bacterial AgentsBacteremiaChildCohort StudiesColoring AgentsCommunity-Acquired InfectionsComorbidityDecision MakingFemaleFeverHumansImmunocompromised HostLength of StayLeukocyte CountLyme DiseaseMagnetic Resonance ImagingMaleMeningitis, AsepticMiddle AgedNeckRetrospective StudiesSeasonsSyphilisTomography, X-Ray ComputedTreatment OutcomeConceptsAcute meningitisComorbid diseasesDiagnostic causesExamination findingsCerebrospinal fluid white blood cell countWhite blood cell countCommunity-acquired illnessPhysicians' management decisionsRetrospective cohort studyEmpiric antibiotic therapyBlood cell countNegative Gram stainMagnetic resonance imagingConcurrent comorbid diseasesEmpiric treatmentCohort studyMedian stayNeck stiffnessAntibiotic therapyClinical outcomesParaclinical dataCranial imagingEmergency departmentFrequent findingTreatable disease
1995
Human Granulocytic Ehrlichiosis in Connecticut: Report of a Fatal Case
Hardalo C, Quagliarello V, Dumler J. Human Granulocytic Ehrlichiosis in Connecticut: Report of a Fatal Case. Clinical Infectious Diseases 1995, 21: 910-914. PMID: 8645839, DOI: 10.1093/clinids/21.4.910.Peer-Reviewed Original ResearchConceptsFifth hospital dayMultisystem organ dysfunctionPeripheral blood smearAcute febrile illnessOutcome of treatmentResults of serological testsHuman granulocytic ehrlichiosisOrgan dysfunctionSevere anemiaCase of human granulocytic ehrlichiosisMechanical ventilationPublished casesFebrile illnessHospital daysIntensive careFatal casesGranulocytic ehrlichiosisEpidemiological associationConvalescent seraDocumented caseSerological testsBlood smearsDeer tick Ixodes scapularisDiagnosisLyme diseasePrimary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients
Quagliarello V, Viscoli C, Horwitz R. Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients. The Lancet 1995, 345: 548-552. PMID: 7776774, DOI: 10.1016/s0140-6736(95)90465-4.Peer-Reviewed Original ResearchConceptsHIV outpatient clinicCryptococcal meningitisFirst episodeCD4 countLumbar punctureUrban HIV outpatient clinicMean CD4 countUniversity Teaching HospitalCase-control studyOral fluconazolePrevious AIDSAntiretroviral therapyCryptococcal antigenCD4 cellsPrimary preventionProtective efficacyControl subjectsInsurance statusOdds ratioOral candidosisTeaching hospitalNumber of visitsCerebrospinal fluidMeningitisHIV