1992
Pathophysiology of Blood-Brain Barrier Alterations during Experimental Haemophilus influenzae Meningitis
Tunkel A, Wispelwey B, Quagliarello V, Rosser S, Lesse A, Hansen E, Scheld W. Pathophysiology of Blood-Brain Barrier Alterations during Experimental Haemophilus influenzae Meningitis. The Journal Of Infectious Diseases 1992, 165: s119-s120. PMID: 1588144, DOI: 10.1093/infdis/165-supplement_1-s119.Peer-Reviewed Original Research
1986
Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase