1991
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
Quagliarello V, Wispelwey B, Long W, Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. Journal Of Clinical Investigation 1991, 87: 1360-1366. PMID: 2010549, PMCID: PMC295174, DOI: 10.1172/jci115140.Peer-Reviewed Original ResearchConceptsBlood-brain barrier injuryRIL-1 betaBBB injuryCerebrospinal fluidBarrier injuryBBB permeabilityInterleukin-1Central nervous system infectionInduction of meningitisNervous system infectionRecombinant human interleukin-1Tumor necrosis factorExperimental rat modelRIL-1 alphaHuman interleukin-1Systemic neutropeniaHost mediatorsCSF inflammationSystem infectionIgG monoclonal antibodiesNeutrophil emigrationRTNF alphaNecrosis factorRat modelIL-1
1989
Potential role of host cytokines in Haemophilus influenzae lipopolysacchar ide-induced blood-brain barrier permeability
SCHELD W, QUAGLIARELLO V, WISPELWEY B. Potential role of host cytokines in Haemophilus influenzae lipopolysacchar ide-induced blood-brain barrier permeability. The Pediatric Infectious Disease Journal 1989, 8: 910. PMID: 2626302, DOI: 10.1097/00006454-198912000-00039.Peer-Reviewed Original Research