2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2019
Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2018
Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
Datta R, Advani S, Rink A, Bianco L, Van Ness PH, Quagliarello V, Juthani-Mehta M. Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report. Open Access Journal Of Gerontology & Geriatric Medicine 2018, 4: 555636. PMID: 30465048, PMCID: PMC6241532, DOI: 10.19080/oajggm.2018.04.555636.Peer-Reviewed Original ResearchLong-term care residentsUrinary tract infectionUrine isolatesCare residentsTract infectionsUncomplicated urinary tract infectionsLong-term care facilitiesTrimethoprim/sulfamethoxazoleEmpiric therapyCommon indicationOptimal therapyUrine cultureUrinary isolatesAntimicrobial therapyClinical trialsNitrofurantoin susceptibilityCare facilitiesFluoroquinolone susceptibilityAntimicrobial susceptibilityPredominant organismTherapyInfectionCefazolinIsolatesBacterial isolates
2000
Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis
Hasbun R, Quagliarello V. Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis. 2000, 325-342. DOI: 10.1016/b978-012059517-4/50012-x.Peer-Reviewed Original ResearchBacterial meningitisAnimal modelsChemoprophylaxis of contactsCerebrospinal fluid penetrationEpidemic meningococcal meningitisNew fluorinated quinolonesCephalosporin-resistant pneumococciGram-negative agentsMajority of casesPediatric populationMeningococcal meningitisMeningitisFluorinated quinolonesClinical experienceQuinolonesTherapyFluid penetrationChemoprophylaxisPatientsHumansMoxifloxacinTrovafloxacinInfectionPneumococciFluoroquinolones
1999
Treatment of bacterial meningitis
Hasbun R, Aronin S, Quagliarello V. Treatment of bacterial meningitis. Comprehensive Therapy 1999, 25: 73-81. PMID: 10091011, DOI: 10.1007/bf02889599.Peer-Reviewed Original ResearchConceptsBacterial meningitisEmergence of penicillinOutcomes of patientsMortality of patientsEffective antibiotic therapyAdjunctive corticosteroidsAntibiotic therapyEpidemiological shiftMeningitisTherapeutic approachesPatientsRoutine useNew antimicrobial agentsPredominant organismAntimicrobial resistanceAntimicrobial agentsGlobal surveillanceTreatmentCorticosteroidsMorbidityTherapyVaccineBetter selectionMortalityInfluenzae
1996
Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS
Villanueva M, Quagliarello V. Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS. CNS Drugs 1996, 5: 246-256. DOI: 10.2165/00023210-199605040-00003.Peer-Reviewed Original ResearchCryptococcal meningitisClinical studiesAggressive initial treatmentLifelong suppressive therapyProspective clinical studySuppressive therapyProlonged immunosuppressionFungal meningitisClinical presentationInitial treatmentRare diagnosisTreatment strategiesAmphotericin BOptimal managementMeningitisPatientsAIDS epidemicTreatmentAIDSDiseaseImmunosuppressionHIVTherapyDiagnosisFluconazole
1992
Yeast Perinephric Abscess: Report of a Case and Review
High K, Quagliarello V. Yeast Perinephric Abscess: Report of a Case and Review. Clinical Infectious Diseases 1992, 15: 128-133. PMID: 1617052, DOI: 10.1093/clinids/15.1.128.Peer-Reviewed Original ResearchConceptsUrinary tract obstructionPerinephric infectionSurgical drainageTract obstructionClinical illnessNonspecific symptomsDiabetes mellitusOverall mortalityRare entitySuccessful therapyEtiologic agentPatientsPerinephricMellitusAbscessSurgeryChronicObstructionTherapyIllnessSymptomsInfectionMortalityCasesAdjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculature