2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer
Lee S, O’Donovan L, Cohen A, Gautam S, Quagliarello V, Juthani-Mehta M, Datta R. Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e152. PMID: 36483405, PMCID: PMC9726473, DOI: 10.1017/ash.2022.293.Peer-Reviewed Original Research
2020
Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialists
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2012
The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients
Ledizet M, Murray TS, Puttagunta S, Slade MD, Quagliarello VJ, Kazmierczak BI. The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients. PLOS ONE 2012, 7: e49578. PMID: 23152923, PMCID: PMC3495863, DOI: 10.1371/journal.pone.0049578.Peer-Reviewed Original ResearchConceptsP. aeruginosa infectionAeruginosa infectionBacterial factorsHospitalized patientsUrinary tractPositive P. aeruginosa culturesP. aeruginosaUrinary tract cathetersP. aeruginosa isolatesLogistic regression modelsPseudomonas aeruginosaProspective cohortDiabetes mellitusSubgroup analysisClinical dataTreatment decisionsClinical diseaseAeruginosa isolatesAnimal modelsPatientsClinical sitesFactor expressionInfectionHost factorsP. aeruginosa cultures
2006
Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia
Sharma G, Han L, Quagliarello V. Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia. Infectious Diseases In Clinical Practice 2006, 14: 365-368. DOI: 10.1097/01.idc.0000227715.26754.e7.Peer-Reviewed Original ResearchCommunity-acquired pneumoniaMonths postdischargeFunctional outcomeLong-term functional outcomeElderly patientsADL declineMean ADLMean ageInclusion criteriaFunctional declineDaily livingPostdischargeElderly adultsPatientsOlder adultsCollected databaseMonthsHospitalizationPneumoniaPotential subjectsAdultsOutcomesIllnessADLDecline
2004
Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults
High K, Juthani-Mehta M, Quagliarello V. Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults. Clinical Infectious Diseases 2004, 38: 692-696. PMID: 14986254, DOI: 10.1086/381688.Peer-Reviewed Original ResearchConceptsPrognostic scoring systemOlder adultsScoring systemAdult populationInfectious diseasesPrimary end pointNumber of patientsGeneral adult populationHealth care needsHealth care costsHeterogeneous adult populationClinical outcomesBloodstream infectionsIndividual patientsCare needsCare costsRelevant outcomesEnd pointClinical predictionDiseasePatientsAdultsFurther investigationCareOutcomes
2001
Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis
Hasbun R, Abrahams J, Jekel J, Quagliarello V. Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis. New England Journal Of Medicine 2001, 345: 1727-1733. PMID: 11742046, DOI: 10.1056/nejmoa010399.Peer-Reviewed Original ResearchConceptsLumbar punctureAbnormal findingsNeurologic abnormalitiesCentral nervous system diseaseAbnormal visual fieldsHealth Stroke ScaleMild mass effectHistory of seizuresUnderwent lumbar punctureNervous system diseasesResults of CTMass effectNegative predictive valueBase lineStroke ScaleClinical characteristicsClinical featuresFacial palsyArm driftCT scanSystem diseasesComputed tomographyPatientsMeningitisPredictive valueCommunity-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death
McMillan D, Lin C, Aronin S, Quagliarello V. Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death. Clinical Infectious Diseases 2001, 33: 969-975. PMID: 11528567, DOI: 10.1086/322612.Peer-Reviewed Original ResearchConceptsCommunity-acquired bacterial meningitisBacterial meningitisTiming of deathImmediate causeSurvival end pointsWorld Health OrganizationMeningitisHealth StatisticsEnd pointUnderlying causeCategorization of causesHealth OrganizationDeathSubstantial proportionCategory IIIPatientsCategory IIAdultsCauseCategory IHospitalizationUtility of prognostic stratification in adults with community-acquired bacterial meningitis
Aronin S, Quagliarello V. Utility of prognostic stratification in adults with community-acquired bacterial meningitis. Comprehensive Therapy 2001, 27: 72-77. PMID: 11280860, DOI: 10.1007/s12019-001-0011-7.Peer-Reviewed Original ResearchNew Perspectives on Pneumococcal Meningitis
Aronin S, Quagliarello V. New Perspectives on Pneumococcal Meningitis. Hospital Practice 2001, 36: 43-51. PMID: 11220360, DOI: 10.3810/hp.2001.02.228.Peer-Reviewed Original Research
2000
Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis
Hasbun R, Quagliarello V. Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis. 2000, 325-342. DOI: 10.1016/b978-012059517-4/50012-x.Peer-Reviewed Original ResearchBacterial meningitisAnimal modelsChemoprophylaxis of contactsCerebrospinal fluid penetrationEpidemic meningococcal meningitisNew fluorinated quinolonesCephalosporin-resistant pneumococciGram-negative agentsMajority of casesPediatric populationMeningococcal meningitisMeningitisFluorinated quinolonesClinical experienceQuinolonesTherapyFluid penetrationChemoprophylaxisPatientsHumansMoxifloxacinTrovafloxacinInfectionPneumococciFluoroquinolones
1999
Treatment of bacterial meningitis
Hasbun R, Aronin S, Quagliarello V. Treatment of bacterial meningitis. Comprehensive Therapy 1999, 25: 73-81. PMID: 10091011, DOI: 10.1007/bf02889599.Peer-Reviewed Original ResearchConceptsBacterial meningitisEmergence of penicillinOutcomes of patientsMortality of patientsEffective antibiotic therapyAdjunctive corticosteroidsAntibiotic therapyEpidemiological shiftMeningitisTherapeutic approachesPatientsRoutine useNew antimicrobial agentsPredominant organismAntimicrobial resistanceAntimicrobial agentsGlobal surveillanceTreatmentCorticosteroidsMorbidityTherapyVaccineBetter selectionMortalityInfluenzaeA prognostic rule for elderly patients admitted with community-acquired pneumonia
Conte H, Chen Y, Mehal W, Phil D, Scinto J, Quagliarello V. A prognostic rule for elderly patients admitted with community-acquired pneumonia. The American Journal Of Medicine 1999, 106: 20-28. PMID: 10320113, DOI: 10.1016/s0002-9343(98)00369-6.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaElderly patientsDerivation cohortValidation cohortStaging systemHeterogeneous adult populationAdult populationHospital mortality ratePrognostic staging systemVital sign abnormalitiesHospital mortalityCreatinine levelsIndependent predictorsMultivariable analysisPrognostic stratificationAdmission characteristicsPneumoniaMortality ratePatientsCohortPrognostic rulesMotor responseMortalityGreater overall accuracyAdmission
1996
Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS
Villanueva M, Quagliarello V. Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS. CNS Drugs 1996, 5: 246-256. DOI: 10.2165/00023210-199605040-00003.Peer-Reviewed Original ResearchCryptococcal meningitisClinical studiesAggressive initial treatmentLifelong suppressive therapyProspective clinical studySuppressive therapyProlonged immunosuppressionFungal meningitisClinical presentationInitial treatmentRare diagnosisTreatment strategiesAmphotericin BOptimal managementMeningitisPatientsAIDS epidemicTreatmentAIDSDiseaseImmunosuppressionHIVTherapyDiagnosisFluconazole
1993
Group B Streptococcal Meningitis in Adults
DUNNE D, QUAGLIARELLO V. Group B Streptococcal Meningitis in Adults. Medicine 1993, 72: 1-10. PMID: 8426534, DOI: 10.1097/00005792-199301000-00001.Peer-Reviewed Original ResearchConceptsGroup B streptococcal meningitisStreptococcal meningitisPercent of patientsCo-morbid illnessHours of symptomsBimodal age distributionConcomitant bacteremiaUnderlying illnessGBS infectionUncommon causeImmunocompromised hostOverall mortalityClinical presentationPyogenic organismsAdult casesRetrospective analysisMeningitisFrequent entityPatientsAdultsIllnessAge distributionHigh percentageBacteremiaImmunocompetent
1992
Yeast Perinephric Abscess: Report of a Case and Review
High K, Quagliarello V. Yeast Perinephric Abscess: Report of a Case and Review. Clinical Infectious Diseases 1992, 15: 128-133. PMID: 1617052, DOI: 10.1093/clinids/15.1.128.Peer-Reviewed Original ResearchConceptsUrinary tract obstructionPerinephric infectionSurgical drainageTract obstructionClinical illnessNonspecific symptomsDiabetes mellitusOverall mortalityRare entitySuccessful therapyEtiologic agentPatientsPerinephricMellitusAbscessSurgeryChronicObstructionTherapyIllnessSymptomsInfectionMortalityCases