2001
Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis
Hasbun R, Abrahams J, Jekel J, Quagliarello V. Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis. New England Journal Of Medicine 2001, 345: 1727-1733. PMID: 11742046, DOI: 10.1056/nejmoa010399.Peer-Reviewed Original ResearchConceptsLumbar punctureAbnormal findingsNeurologic abnormalitiesCentral nervous system diseaseAbnormal visual fieldsHealth Stroke ScaleMild mass effectHistory of seizuresUnderwent lumbar punctureNervous system diseasesResults of CTMass effectNegative predictive valueBase lineStroke ScaleClinical characteristicsClinical featuresFacial palsyArm driftCT scanSystem diseasesComputed tomographyPatientsMeningitisPredictive valueCommunity-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death
McMillan D, Lin C, Aronin S, Quagliarello V. Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death. Clinical Infectious Diseases 2001, 33: 969-975. PMID: 11528567, DOI: 10.1086/322612.Peer-Reviewed Original ResearchConceptsCommunity-acquired bacterial meningitisBacterial meningitisTiming of deathImmediate causeSurvival end pointsWorld Health OrganizationMeningitisHealth StatisticsEnd pointUnderlying causeCategorization of causesHealth OrganizationDeathSubstantial proportionCategory IIIPatientsCategory IIAdultsCauseCategory IHospitalizationUtility of prognostic stratification in adults with community-acquired bacterial meningitis
Aronin S, Quagliarello V. Utility of prognostic stratification in adults with community-acquired bacterial meningitis. Comprehensive Therapy 2001, 27: 72-77. PMID: 11280860, DOI: 10.1007/s12019-001-0011-7.Peer-Reviewed Original ResearchNew Perspectives on Pneumococcal Meningitis
Aronin S, Quagliarello V. New Perspectives on Pneumococcal Meningitis. Hospital Practice 2001, 36: 43-51. PMID: 11220360, DOI: 10.3810/hp.2001.02.228.Peer-Reviewed Original Research
2000
Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis
Hasbun R, Quagliarello V. Chapter 11 Use of the Quinolones in Treatment of Bacterial Meningitis. 2000, 325-342. DOI: 10.1016/b978-012059517-4/50012-x.Peer-Reviewed Original ResearchBacterial meningitisAnimal modelsChemoprophylaxis of contactsCerebrospinal fluid penetrationEpidemic meningococcal meningitisNew fluorinated quinolonesCephalosporin-resistant pneumococciGram-negative agentsMajority of casesPediatric populationMeningococcal meningitisMeningitisFluorinated quinolonesClinical experienceQuinolonesTherapyFluid penetrationChemoprophylaxisPatientsHumansMoxifloxacinTrovafloxacinInfectionPneumococciFluoroquinolones
1999
Treatment of bacterial meningitis
Hasbun R, Aronin S, Quagliarello V. Treatment of bacterial meningitis. Comprehensive Therapy 1999, 25: 73-81. PMID: 10091011, DOI: 10.1007/bf02889599.Peer-Reviewed Original ResearchConceptsBacterial meningitisEmergence of penicillinOutcomes of patientsMortality of patientsEffective antibiotic therapyAdjunctive corticosteroidsAntibiotic therapyEpidemiological shiftMeningitisTherapeutic approachesPatientsRoutine useNew antimicrobial agentsPredominant organismAntimicrobial resistanceAntimicrobial agentsGlobal surveillanceTreatmentCorticosteroidsMorbidityTherapyVaccineBetter selectionMortalityInfluenzaeAntibiotic timing and risk stratification system in the management of community-acquired bacterial meningitis
Aronin S, Peduzzi P, Quagliarello V. Antibiotic timing and risk stratification system in the management of community-acquired bacterial meningitis. Journal Of Osteopathic Medicine 1999, 99: 83-83. DOI: 10.7556/jaoa.1999.99.2.83.Peer-Reviewed Original Research
1996
Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS
Villanueva M, Quagliarello V. Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS. CNS Drugs 1996, 5: 246-256. DOI: 10.2165/00023210-199605040-00003.Peer-Reviewed Original ResearchCryptococcal meningitisClinical studiesAggressive initial treatmentLifelong suppressive therapyProspective clinical studySuppressive therapyProlonged immunosuppressionFungal meningitisClinical presentationInitial treatmentRare diagnosisTreatment strategiesAmphotericin BOptimal managementMeningitisPatientsAIDS epidemicTreatmentAIDSDiseaseImmunosuppressionHIVTherapyDiagnosisFluconazole
1995
Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients
Quagliarello V, Viscoli C, Horwitz R. Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients. The Lancet 1995, 345: 548-552. PMID: 7776774, DOI: 10.1016/s0140-6736(95)90465-4.Peer-Reviewed Original ResearchConceptsHIV outpatient clinicCryptococcal meningitisFirst episodeCD4 countLumbar punctureUrban HIV outpatient clinicMean CD4 countUniversity Teaching HospitalCase-control studyOral fluconazolePrevious AIDSAntiretroviral therapyCryptococcal antigenCD4 cellsPrimary preventionProtective efficacyControl subjectsInsurance statusOdds ratioOral candidosisTeaching hospitalNumber of visitsCerebrospinal fluidMeningitisHIV
1993
Group B Streptococcal Meningitis in Adults
DUNNE D, QUAGLIARELLO V. Group B Streptococcal Meningitis in Adults. Medicine 1993, 72: 1-10. PMID: 8426534, DOI: 10.1097/00005792-199301000-00001.Peer-Reviewed Original ResearchConceptsGroup B streptococcal meningitisStreptococcal meningitisPercent of patientsCo-morbid illnessHours of symptomsBimodal age distributionConcomitant bacteremiaUnderlying illnessGBS infectionUncommon causeImmunocompromised hostOverall mortalityClinical presentationPyogenic organismsAdult casesRetrospective analysisMeningitisFrequent entityPatientsAdultsIllnessAge distributionHigh percentageBacteremiaImmunocompetent
1992
Pathophysiology of Blood-Brain Barrier Alterations during Experimental Haemophilus influenzae Meningitis
Tunkel A, Wispelwey B, Quagliarello V, Rosser S, Lesse A, Hansen E, Scheld W. Pathophysiology of Blood-Brain Barrier Alterations during Experimental Haemophilus influenzae Meningitis. The Journal Of Infectious Diseases 1992, 165: s119-s120. PMID: 1588144, DOI: 10.1093/infdis/165-supplement_1-s119.Peer-Reviewed Original ResearchAdjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculature
1991
Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat.
Quagliarello V, Ma A, Stukenbrok H, Palade G. Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat. Journal Of Experimental Medicine 1991, 174: 657-672. PMID: 1875166, PMCID: PMC2118932, DOI: 10.1084/jem.174.3.657.Peer-Reviewed Original ResearchConceptsBlood-brain barrierBBB injuryExperimental meningitisCerebral microvasculatureOpen intercellular junctionsSpecific therapeutic interventionsBacterial meningitisBrain barrierIntracisternal inoculationMeningitisBrain cortexInjury mechanismMicrovascular segmentsTherapeutic interventionsIntercellular junctionsInducible increaseAu-BSAInjuryAbluminal sidePrecise mechanismSimilar uptakeAlbumin transportColloidal carbonTracer perfusionVenular leaks
1986
Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis
Quagliarello V, Scheld W. Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis. The American Journal Of The Medical Sciences 1986, 292: 306-309. PMID: 3535498, DOI: 10.1097/00000441-198611000-00010.Peer-Reviewed Original ResearchConceptsBacterial meningitisHost defenseBactericidal antibiotic therapyInterstitial brain edemaIrreversible neuronal injuryBlood-brain barrier penetrationImpaired host defenseExperimental animal modelsVirulence factorsBrain barrier penetrationSurface virulence factorsBacterial virulence factorsMeningitis developmentPathophysiologic sequelaeMeningeal pathogensNeuronal injuryAntibiotic therapyBrain edemaWorldwide morbidityPathogenetic sequencePathogenetic stepsAnimal modelsMucosal colonizationMeningitisMorbidityMorphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase