Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis
Quagliarello V, Scheld W. Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis. The American Journal Of The Medical Sciences 1986, 292: 306-309. PMID: 3535498, DOI: 10.1097/00000441-198611000-00010.Peer-Reviewed Original ResearchConceptsBacterial meningitisHost defenseBactericidal antibiotic therapyInterstitial brain edemaIrreversible neuronal injuryBlood-brain barrier penetrationImpaired host defenseExperimental animal modelsVirulence factorsBrain barrier penetrationSurface virulence factorsBacterial virulence factorsMeningitis developmentPathophysiologic sequelaeMeningeal pathogensNeuronal injuryAntibiotic therapyBrain edemaWorldwide morbidityPathogenetic sequencePathogenetic stepsAnimal modelsMucosal colonizationMeningitisMorbidityMorphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase