1992
Adjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculature
1991
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
Quagliarello V, Wispelwey B, Long W, Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. Journal Of Clinical Investigation 1991, 87: 1360-1366. PMID: 2010549, PMCID: PMC295174, DOI: 10.1172/jci115140.Peer-Reviewed Original ResearchConceptsBlood-brain barrier injuryRIL-1 betaBBB injuryCerebrospinal fluidBarrier injuryBBB permeabilityInterleukin-1Central nervous system infectionInduction of meningitisNervous system infectionRecombinant human interleukin-1Tumor necrosis factorExperimental rat modelRIL-1 alphaHuman interleukin-1Systemic neutropeniaHost mediatorsCSF inflammationSystem infectionIgG monoclonal antibodiesNeutrophil emigrationRTNF alphaNecrosis factorRat modelIL-1