1991
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
Quagliarello V, Wispelwey B, Long W, Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. Journal Of Clinical Investigation 1991, 87: 1360-1366. PMID: 2010549, PMCID: PMC295174, DOI: 10.1172/jci115140.Peer-Reviewed Original ResearchConceptsBlood-brain barrier injuryRIL-1 betaBBB injuryCerebrospinal fluidBarrier injuryBBB permeabilityInterleukin-1Central nervous system infectionInduction of meningitisNervous system infectionRecombinant human interleukin-1Tumor necrosis factorExperimental rat modelRIL-1 alphaHuman interleukin-1Systemic neutropeniaHost mediatorsCSF inflammationSystem infectionIgG monoclonal antibodiesNeutrophil emigrationRTNF alphaNecrosis factorRat modelIL-1
1986
Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase