2024
Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia
Lee S, Benson J, Cohen A, Quagliarello V, Juthani-Mehta M, Datta R. Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e48. PMID: 38655023, PMCID: PMC11036428, DOI: 10.1017/ash.2024.54.Peer-Reviewed Original ResearchNon-ventilator hospital-acquired pneumoniaAdvanced cancerPalliative care settingHospital-acquired pneumoniaCohort study of patientsCare settingsOlder adultsAdjusted oddsDuration of antibiotic therapyAssociated with reduced adjusted oddsSingle-center observational studyCohort studyProlonged antibiotic durationObservational studyStudy of patientsAntimicrobial stewardship effortsAntibiotic durationAntibiotic therapyStewardship effortsPneumoniaCancerOddsReadmissionAdultsCohort
2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
1999
Treatment of bacterial meningitis
Hasbun R, Aronin S, Quagliarello V. Treatment of bacterial meningitis. Comprehensive Therapy 1999, 25: 73-81. PMID: 10091011, DOI: 10.1007/bf02889599.Peer-Reviewed Original ResearchConceptsBacterial meningitisEmergence of penicillinOutcomes of patientsMortality of patientsEffective antibiotic therapyAdjunctive corticosteroidsAntibiotic therapyEpidemiological shiftMeningitisTherapeutic approachesPatientsRoutine useNew antimicrobial agentsPredominant organismAntimicrobial resistanceAntimicrobial agentsGlobal surveillanceTreatmentCorticosteroidsMorbidityTherapyVaccineBetter selectionMortalityInfluenzae
1996
Acute meningitis with a negative gram's stain: Clinical and management outcomes in 171 episodes
Elmore J, Horwitz R, Quagliarello V. Acute meningitis with a negative gram's stain: Clinical and management outcomes in 171 episodes. The American Journal Of Medicine 1996, 100: 78-84. PMID: 8579091, DOI: 10.1016/s0002-9343(96)90015-7.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAnti-Bacterial AgentsBacteremiaChildCohort StudiesColoring AgentsCommunity-Acquired InfectionsComorbidityDecision MakingFemaleFeverHumansImmunocompromised HostLength of StayLeukocyte CountLyme DiseaseMagnetic Resonance ImagingMaleMeningitis, AsepticMiddle AgedNeckRetrospective StudiesSeasonsSyphilisTomography, X-Ray ComputedTreatment OutcomeConceptsAcute meningitisComorbid diseasesDiagnostic causesExamination findingsCerebrospinal fluid white blood cell countWhite blood cell countCommunity-acquired illnessPhysicians' management decisionsRetrospective cohort studyEmpiric antibiotic therapyBlood cell countNegative Gram stainMagnetic resonance imagingConcurrent comorbid diseasesEmpiric treatmentCohort studyMedian stayNeck stiffnessAntibiotic therapyClinical outcomesParaclinical dataCranial imagingEmergency departmentFrequent findingTreatable disease
1992
Adjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculatureEndovascular Infections Arising from Right-Sided Heart Structures
Remetz M, Quagliarello V. Endovascular Infections Arising from Right-Sided Heart Structures. Cardiology Clinics 1992, 10: 137-149. PMID: 1739955, DOI: 10.1016/s0733-8651(18)30259-5.Peer-Reviewed Original ResearchConceptsRight-sided endocarditisRight-sided heart failureLeft-sided endocarditisAntibiotic therapyHeart failureClinical manifestationsWorse prognosisTricuspid valveEndovascular infectionProgressive right-sided heart failureS. aureusMultiple septic pulmonary emboliSeptic pulmonary emboliInitial antibiotic therapyCombination antibiotic therapyCommon predisposing factorsCases of endocarditisCongenital heart diseaseViridans group streptococciCoexistent infectionPleuritic painProductive coughSignificant murmurPulmonary infarctionCardiac manifestations
1986
Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis
Quagliarello V, Scheld W. Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis. The American Journal Of The Medical Sciences 1986, 292: 306-309. PMID: 3535498, DOI: 10.1097/00000441-198611000-00010.Peer-Reviewed Original ResearchConceptsBacterial meningitisHost defenseBactericidal antibiotic therapyInterstitial brain edemaIrreversible neuronal injuryBlood-brain barrier penetrationImpaired host defenseExperimental animal modelsVirulence factorsBrain barrier penetrationSurface virulence factorsBacterial virulence factorsMeningitis developmentPathophysiologic sequelaeMeningeal pathogensNeuronal injuryAntibiotic therapyBrain edemaWorldwide morbidityPathogenetic sequencePathogenetic stepsAnimal modelsMucosal colonizationMeningitisMorbidity